A selective fluorescent probe for thiols based on α,β- unsaturated acyl sulfonamide

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

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Original languageEnglish
Pages (from-to)10672-10674
Journal / PublicationChemical Communications
Volume48
Issue number86
Publication statusPublished - 7 Nov 2012

Abstract

We report herein a novel fluorescent probe based on α,β- unsaturated acyl sulfonamide to detect thiols. The probe has good water solubility and reacts with thiols under aqueous conditions. It reacts selectively with cysteine but not with the other natural amino acids. The probe was subsequently applied to detect intracellular thiols. © 2012 The Royal Society of Chemistry.