MULTINUCLEAR ORGANOMETALLIC RUTHENIUM-ARENE COMPLEXES FOR CANCER THERAPY
Research output: Chapters, Conference Papers, Creative and Literary Works (RGC: 12, 32, 41, 45) › 12_Chapter in an edited book (Author) › peer-review
Author(s)
Detail(s)
| Original language | English |
|---|---|
| Title of host publication | Metallo-Drugs |
| Subtitle of host publication | Development and Action of Anticancer Agents |
| Editors | Astrid Sigel, Helmut Sigel, Eva Freisinger |
| Publisher | Walter de Gruyter GmbH |
| Chapter | 6 |
| Pages | 171-198 |
| ISBN (Electronic) | 9783110470734, 9783110469905 |
| ISBN (Print) | 9783110469844, 9783110470741 |
| Publication status | Published - 2018 |
| Externally published | Yes |
Publication series
| Name | Metal Ions in Life Sciences |
|---|---|
| Volume | 18 |
| ISSN (Print) | 1559-0836 |
| ISSN (Electronic) | 1868-0402 |
Link(s)
Abstract
There has been much recent interest in the development of therapeutic transition metal-based complexes in part fueled by the clinical success of the platinum(II) anticancer drug, cisplatin. Yet known platinum drugs are limited by their high toxicity, severe side-effects, and incidences of drug resistance. Organometallic ruthenium-arene complexes have risen to prominence as a pharmacophore due to the success of other ruthenium drug candidates in clinical trials. In this chapter, we highlight higher order multinuclear ruthenium-arene complexes and their respective investigations as chemotherapeutic agents. We discuss their unique structural properties and the associated biochemical evaluation in the context of anticancer drug design. We also review the structural considerations for the design of these scaffolds and new therapeutic applications that are uncovered for this class of complexes.
Research Area(s)
- Arene ligands, Cancer therapy, Heterometallic complexes, Multinuclear complexes, Ruthenium
Citation Format(s)
MULTINUCLEAR ORGANOMETALLIC RUTHENIUM-ARENE COMPLEXES FOR CANCER THERAPY. / Babak, Maria V.; Ang, Wee Han.
Metallo-Drugs: Development and Action of Anticancer Agents. ed. / Astrid Sigel; Helmut Sigel; Eva Freisinger. Walter de Gruyter GmbH, 2018. p. 171-198 (Metal Ions in Life Sciences; Vol. 18).Research output: Chapters, Conference Papers, Creative and Literary Works (RGC: 12, 32, 41, 45) › 12_Chapter in an edited book (Author) › peer-review
