Toxicity and estrogenic endocrine disrupting activity of phthalates and their mixtures

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

153 Scopus Citations
View graph of relations

Author(s)

  • Xueping Chen
  • Shisan Xu
  • Tianfeng Tan
  • Sin Ting Lee
  • Fred Wang Fat Lee
  • Steven Jing Liang Xu
  • Kin Chung Ho

Detail(s)

Original languageEnglish
Pages (from-to)3156-3168
Journal / PublicationInternational Journal of Environmental Research and Public Health
Volume11
Issue number3
Online published14 Mar 2014
Publication statusPublished - Mar 2014

Link(s)

Abstract

Phthalates, widely used in flexible plastics and consumer products, have become ubiquitous contaminants worldwide. This study evaluated the acute toxicity and estrogenic endocrine disrupting activity of butyl benzyl phthalate (BBP), di(n-butyl) phthalate (DBP), bis(2-ethylhexyl) phthalate (DEHP), diisodecyl phthalate (DIDP), diisononyl phthalate (DINP), di-n-octyl phthalate (DNOP) and their mixtures. Using a 72 h zebrafish embryo toxicity test, the LC50 values of BBP, DBP and a mixture of the six phthalates were found to be 0.72, 0.63 and 0.50 ppm, respectively. The other four phthalates did not cause more than 50% exposed embryo mortality even at their highest soluble concentrations. The typical toxicity symptoms caused by phthalates were death, tail curvature, necrosis, cardio edema and no touch response. Using an estrogen-responsive ChgH-EGFP transgenic medaka (Oryzias melastigma) eleutheroembryos based 24 h test, BBP demonstrated estrogenic activity, DBP, DEHP, DINP and the mixture of the six phthalates exhibited enhanced-estrogenic activity and DIDP and DNOP showed no enhanced- or anti-estrogenic activity. These findings highlighted the developmental toxicity of BBP and DBP, and the estrogenic endocrine disrupting activity of BBP, DBP, DEHP and DINP on intact organisms, indicating that the widespread use of these phthalates may cause potential health risks to human beings. © 2014 by the authors; licensee MDPI, Basel, Switzerland.

Research Area(s)

  • Enhanced-estrogenic activity, Estrogenic activity, Estrogenic endocrine disruptor, Mixture effects, Phthalate, Toxicity

Citation Format(s)

Toxicity and estrogenic endocrine disrupting activity of phthalates and their mixtures. / Chen, Xueping; Xu, Shisan; Tan, Tianfeng; Lee, Sin Ting; Cheng, Shuk Han; Lee, Fred Wang Fat; Xu, Steven Jing Liang; Ho, Kin Chung.

In: International Journal of Environmental Research and Public Health, Vol. 11, No. 3, 03.2014, p. 3156-3168.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

Download Statistics

No data available