Enantiospecific Uptake and Depuration Kinetics of Chiral Metoprolol and Venlafaxine in Marine Medaka (Oryzias melastigma) : Tissue Distribution and Metabolite Formation

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review

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Author(s)

  • Linjie Jin
  • Kai Zhang
  • Paul K. S. Lam

Detail(s)

Original languageEnglish
Pages (from-to)4471-4480
Journal / PublicationEnvironmental Science & Technology
Volume57
Issue number11
Online published6 Mar 2023
Publication statusPublished - 21 Mar 2023

Abstract

The increasing use of chiral pharmaceuticals has led to their widespread presence in the environment. However, their toxicokinetics have rarely been reported. Therefore, the tissue-specific uptake and depuration kinetics of two pairs of pharmaceutical enantiomers, S-(-)-metoprolol versus R-(+)-metoprolol and S- (+)-venlafaxine versus R-(-)-venlafaxine, were studied in marine medaka (Oryzias melastigma) during a 28-day exposure and 14-day clearance period. The toxicokinetics of the studied pharmaceuticals, including uptake and depuration rate constants, depuration half-life (t1/2), and bioconcentration factor (BCF), were reported for the first time. The whole-fish results demonstrated a higher S- than R-venlafaxine bioaccumulation potential, whereas no significant difference was observed between S- and R-metoprolol. O-desmethyl-metoprolol (ODM) and alpha-hydroxy-metoprolol (AHM) were the main metoprolol metabolites identified by suspect screening, and the ratios of ODM to AHM were 3.08 and 1.35 for S- and R-metoprolol, respectively. N,O-Didesmethyl-venlafaxine (NODDV) and N-desmethyl-venlafaxine (NDV) were the main venlafaxine metabolites, and the ratios of NODDV to NDV were 1.55 and 0.73 for S- and R-venlafaxine, respectively. The highest tissue-specific BCFs of the four enantiomers were all found in the eyes, meriting indepth investigation. © 2023 American Chemical Society

Research Area(s)

  • antidepressant, ?-blocker, enantiomer, toxicokinetics, eyes, suspect screening, metabolites, PERSONAL CARE PRODUCTS, BETA-BLOCKERS, LIQUID-CHROMATOGRAPHY, PHARMACEUTICALS, ENVIRONMENT, BIOCONCENTRATION, FATE, PHARMACOKINETICS, BIOACCUMULATION, DEGRADATION

Citation Format(s)

Enantiospecific Uptake and Depuration Kinetics of Chiral Metoprolol and Venlafaxine in Marine Medaka (Oryzias melastigma): Tissue Distribution and Metabolite Formation. / Jin, Linjie; Wang, Qi; Yan, Meng et al.
In: Environmental Science & Technology, Vol. 57, No. 11, 21.03.2023, p. 4471-4480.

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review