Drawing on an extended resource-based view, we investigate the moderating roles of both intra- and inter-organizational factors on the relationship between entrepreneurial orientation (EO) and firm performance. Specifically, we examine organizational structure (centralization and formalization) and coordination (knowledge integration), as well as firms’ connections with external stakeholders (business versus institutional networks). Using survey data from 547 Chinese firms in two industries, we find that centralization strengthens the positive relationship between EO and performance, while formalization weakens it. Interestingly, a firm’s business network also strengthens this relationship, while its institutional network dampens it. Finally, knowledge integration positively moderates this relationship.