Prenatal transfer of polybrominated diphenyl ethers (PBDEs) results in developmental neurotoxicity in zebrafish larvae

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

108 Scopus Citations
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Author(s)

  • Lianguo Chen
  • Ke Yu
  • Changjiang Huang
  • Liqin Yu
  • Bingqing Zhu
  • And 3 others
  • Paul K. S. Lam
  • James C. W. Lam
  • Bingsheng Zhou

Detail(s)

Original languageEnglish
Pages (from-to)9727-9734
Journal / PublicationEnvironmental Science and Technology
Volume46
Issue number17
Publication statusPublished - 4 Sep 2012

Abstract

Parental exposure to polybrominated diphenyl ethers (PBDEs) in animals has been found to be transferred to the offspring. The environmental health risk and toxicity to the offspring are still unclear. The objective of the present study was to identify environmentally relevant concentrations of PBDEs for parental exposure that would cause developmental neurotoxicity in the offspring. Adult zebrafish were exposed to environmentally relevant concentrations of DE-71 (0.16, 0.8, 4.0 μg/L) via water. The results showed that PBDE exposure did not affect larvae hatching, malformation, or survival. The residue of PBDEs was detected in F1 eggs upon parental exposure. Acetylcholinesterase (AChE) activity was significantly inhibited in F1 larvae. Genes of central nervous system development (e.g., myelin basic protein, synapsin IIa, α1-tubulin) were significantly downregulated in larvae. Protein levels of α1-tubulin and synapsin IIa were also reduced. Decreased locomotion activity was observed in the larvae. This study provides the first evidence that parental exposure to environmentally relevant concentrations of PBDEs could cause adverse effects on neurodevelopment in zebrafish offspring. © 2012 American Chemical Society.

Citation Format(s)

Prenatal transfer of polybrominated diphenyl ethers (PBDEs) results in developmental neurotoxicity in zebrafish larvae. / Chen, Lianguo; Yu, Ke; Huang, Changjiang; Yu, Liqin; Zhu, Bingqing; Lam, Paul K. S.; Lam, James C. W.; Zhou, Bingsheng.

In: Environmental Science and Technology, Vol. 46, No. 17, 04.09.2012, p. 9727-9734.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review