Development of Novel Implants with Self-Antibacterial Performance through In-Situ Growth of 1D ZnO Nanowire

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

22 Scopus Citations
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Author(s)

  • Wenhao Wang
  • Tak Lung Li
  • Hoi Man Wong
  • Richard Y. T. Kao
  • Shuilin Wu
  • Frankie K. L. Leung
  • Tak Man Wong
  • Michael K. T. To
  • Kenneth M. C. Cheung
  • Kelvin W. K. Yeung

Detail(s)

Original languageEnglish
Pages (from-to)623-633
Journal / PublicationColloids and Surfaces B: Biointerfaces
Volume141
Online published18 Feb 2016
Publication statusPublished - 1 May 2016

Abstract

To prevent the attachment of bacteria to implant surfaces, the 1D zinc oxide nanowire-coating has been successfully developed on material surfaces by using a custom-made hydrothermal approach. The chemical nature, surface topography and wettability of spike-like 1D ZnO nanowire-coating are comprehensively investigated. The anti-adhesive and antimicrobial properties of 1D nanowire-coating are tested against Staphylococcus aureus, Pseudomonas aeruginosa and Escherichia coli by using in vitro live/dead staining and scanning electron microscopy. We find that the adhesion of bacteria can be reduced via the special spike-like topography and that the release of Zn2+ ions can help suppress the growth of attached bacteria. Furthermore, the antimicrobial effect is also evaluated under in vivo conditions by using a rat model infected with bioluminescent S. aureus. The amount of live bacteria in the rat implanted with a nanowire-coated sample is less than that of the control at various time points. Hence, it is believed that the nanowire-coated material is promising for application in orthopaedic implantation after the long-term animal studies have been completed.

Research Area(s)

  • ZnO nanowire, Self-antibacterial effect, Surface modification, Bioluminescent bacteria

Citation Format(s)

Development of Novel Implants with Self-Antibacterial Performance through In-Situ Growth of 1D ZnO Nanowire. / Wang, Wenhao; Li, Tak Lung; Wong, Hoi Man; Chu, Paul K. ; Kao, Richard Y. T.; Wu, Shuilin; Leung , Frankie K. L.; Wong, Tak Man; To, Michael K. T.; Cheung, Kenneth M. C.; Yeung, Kelvin W. K.

In: Colloids and Surfaces B: Biointerfaces, Vol. 141, 01.05.2016, p. 623-633.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review