Phosphonium-Ring-Fused Bicyclic Metallafuran Complexes of Ruthenium and Osmium

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

19 Scopus Citations
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Author(s)

  • Lai-Hon Chung
  • Sheung-Ying Tse
  • Siu-Chung Chan
  • Man-Kit Tse
  • Shek-Man Yiu

Detail(s)

Original languageEnglish
Pages (from-to)9159-9163
Journal / PublicationChemistry - A European Journal
Volume25
Issue number39
Online published29 Apr 2019
Publication statusPublished - 11 Jul 2019

Abstract

Metallafuran complexes with a fused five-membered phosphonium ring were synthesized from reactions between terminal ynones HC≡C(C=O)R and cis-[Ru/Os(dppm)2Cl2] (dppm=1,1-bis(diphenylphosphino)methane). A metal–vinylidene-involving pathway was found to be an energetically feasible formation mechanism for these complexes. These phosphonium-containing metallafurans, like many phosphonium-functionalized drugs, have the ability to induce mitochondrial dysfunction. They also exhibit stronger cytotoxicity against several human cancer cell lines in comparison with their metal precursors and the classic anticancer drug cisplatin. Overall, this work provides structural and mechanistic insights for the rational design of functional metallacycles via activation of alkynes by RuII and OsII centers.

Research Area(s)

  • alkyne activation, metallacycles, osmium, ruthenium

Citation Format(s)

Phosphonium-Ring-Fused Bicyclic Metallafuran Complexes of Ruthenium and Osmium. / Yeung, Chi-Fung; Chung, Lai-Hon; Ng, Sze-Wing et al.

In: Chemistry - A European Journal, Vol. 25, No. 39, 11.07.2019, p. 9159-9163.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review