Transparent and Gas-Permeable Liquid Marbles for Culturing and Drug Sensitivity Test of Tumor Spheroids

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

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Detail(s)

Original languageEnglish
Article number1700185
Journal / PublicationAdvanced Healthcare Materials
Volume6
Issue number13
Online published20 Apr 2017
Publication statusPublished - 5 Jul 2017

Abstract

Transparent nanoparticle-based liquid marbles with high gas-permeability are prepared to culture tumor spheroids in 3D without the need of supplementary growth factor. The culturing process of spheroids from a population of cancer cells or a single cell in the transparent liquid marbles can be optically recorded continuously. Compared to monolayer cells and spheroids generated in multiwell plate, tumor spheroids cultured in the liquid marbles show enhanced viability under the treatment of chemotherapeutic drugs and small interfering RNA.

Research Area(s)

  • high-throughput screening, in situ monitoring, liquid marble, nanoparticle, tumor spheroid