A modified multiple alignment fast Fourier transform with higher efficiency

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

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Original languageEnglish
Article number7407334
Pages (from-to)634-645
Journal / PublicationIEEE/ACM Transactions on Computational Biology and Bioinformatics
Issue number3
Publication statusPublished - May 2017


Multiple sequence alignment (MSA) is the most common task in bioinformatics. Multiple alignment fast Fourier transform (MAFFT) is the fastest MSA program among those the accuracy of the resulting alignments can be comparable with the most accurate MSA programs. In this paper, we modify the correlation computation scheme of the MAFFT for further efficiency improvement in three aspects. First, novel complex number based amino acid and nucleotide expressions are utilized in the modified correlation. Second, linear convolution with a limitation is proposed for computing the correlation of amino acid and nucleotide sequences. Third, we devise a fast Fourier transform (FFT) algorithm for computing linear convolution. The FFT algorithm is based on conjugate pair split-radix FFT and does not require the permutation of order, and it is new as only real parts of the final outputs are required. Simulation results show that the speed of the modified scheme is 107.58 to 365.74 percent faster than that of the original MAFFT for one execution of the function Falign() of MAFFT, indicating its faster realization.

Research Area(s)

  • Convolution, fast Fourier transform (FFT), MAFFT, multiple sequence alignment (MSA)