Microdevices for Non-Invasive Detection of Bladder Cancer

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

5 Scopus Citations
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  • Constantine Tzouanas
  • Joey Sze Yun Lim
  • Ya Wen
  • Jean Paul Thiery
  • Bee Luan Khoo


Original languageEnglish
Article number30
Journal / PublicationChemosensors
Issue number4
Online published19 Nov 2017
Publication statusPublished - Dec 2017
Externally publishedYes



Bladder cancer holds the record for the highest lifetime cost on a per-patient basis. This is due to high recurrence rates, which necessitate invasive and costly long-term evaluation methods such as cystoscopy and imaging. Microfluidics is emerging as an important approach to contribute to initial diagnosis and follow-up, by enabling the precise manipulation of biological samples. Specifically, microdevices have been used for the isolation of cells or genetic material from blood samples, sparking significant interest as a versatile platform for non-invasive bladder cancer detection with voided urine. In this review, we revisit the methods of bladder cancer detection and describe various types of markers currently used for evaluation. We detail cutting-edge technologies and evaluate their merits in the detection, screening, and diagnosis of bladder cancer. Advantages of microscale devices over standard methods of detection, as well as their limitations, are provided. We conclude with a discussion of criteria for guiding microdevice development that could deepen our understanding of prognoses at the level of individual patients and the underlying biology of bladder cancer development. Collectively, the development and widespread application of improved microfluidic devices for bladder cancer could drive treatment breakthroughs and establish widespread, tangible outcomes on patients' long-term survival.

Research Area(s)

  • bladder cancer, microdevices, non-invasive procedures, urine

Citation Format(s)

Microdevices for Non-Invasive Detection of Bladder Cancer. / Tzouanas, Constantine; Lim, Joey Sze Yun; Wen, Ya et al.

In: Chemosensors, Vol. 5, No. 4, 30, 12.2017.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

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