Facile functionalization and phase reduction route of magnetic iron oxide nanoparticles for conjugation of matrix metalloproteinase

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

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Author(s)

  • Dan Li
  • Diana Djunaedi
  • Jolen Justin Gooding
  • Cordelia Selomulya
  • Rose Amal

Detail(s)

Original languageEnglish
Journal / PublicationAdvanced Engineering Materials
Volume12
Issue number6
Publication statusPublished - Jun 2010
Externally publishedYes

Abstract

A protocol for the simultaneous functionalization and phase reduction route of iron oxide magnetic nanoparticles (MNPs) and its further bioconjugation is presented. It was found that surface functionalization of maghemite (γ-Fe2O3) nanoparticles with mercaptopropyltrimethoxysilane (MPTMS) under anoxic environment at above 80 °C promotes in situ conversion to magnetite (Fe3O4). Full conversion to Fe3O4, as probed by Mössbauer spectroscopy, with accompanied increase in the composite saturation magnetization, was achieved at 120 °C. By controlling the MPTMS concentration, the resultant silane-MNPs morphology can be tuned from having homogeneous thin layer (2-weighted MRI contrast can be achieved simultaneously. © 2010 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Citation Format(s)

Facile functionalization and phase reduction route of magnetic iron oxide nanoparticles for conjugation of matrix metalloproteinase. / Li, Dan; Teoh, Wey Yang; Djunaedi, Diana; Gooding, Jolen Justin; Selomulya, Cordelia; Amal, Rose.

In: Advanced Engineering Materials, Vol. 12, No. 6, 06.2010.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review