Endothelial dysfunction : The common consequence in diabetes and hypertension

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

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  • Wing Tak Wong
  • Siu Ling Wong
  • Xiao Yu Tian
  • Yu Huang


Original languageEnglish
Pages (from-to)300-307
Journal / PublicationJournal of Cardiovascular Pharmacology
Issue number4
Publication statusPublished - Apr 2010
Externally publishedYes


Endothelial dysfunction plays a key role in the initiation of cellular events evolving into the development of vascular complications in diabetes and hypertension. Diminished production and function of endothelium-derived nitric oxide and other vasoprotective factors and/or the exaggerated production of proinflammatory and vasoconstrictors such as angiotensin II, endothelin-1, reactive oxygen species, and cyclooxygenase-derived metabolites of arachidonic acid eventually lead to endothelial dysfunction, resulting in elevated vascular tone which contributes to hypertension, vascular, and cardiac remodeling, culminating in microvascular, macrovascular, and renal damages. Specific therapies targeting reactive oxygen species using antioxidants and inhibitors of the rennin-angiotensin system or increasing endothelial nitric oxide synthase activity might assist to reverse endothelial dysfunction and thus reduce the related cardiovascular morbidity and mortality in diabetes and hypertension. © 2010 by Lippincott Williams & Wilkins.

Research Area(s)

  • Diabetes, Endothelial dysfunction, Hypertension

Bibliographic Note

Publication details (e.g. title, author(s), publication statuses and dates) are captured on an “AS IS” and “AS AVAILABLE” basis at the time of record harvesting from the data source. Suggestions for further amendments or supplementary information can be sent to lbscholars@cityu.edu.hk.

Citation Format(s)

Endothelial dysfunction: The common consequence in diabetes and hypertension. / Wong, Wing Tak; Wong, Siu Ling; Tian, Xiao Yu et al.
In: Journal of Cardiovascular Pharmacology, Vol. 55, No. 4, 04.2010, p. 300-307.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review