Wide-field photoacoustic microscopy of oxygen saturation at 1-MHz A-line rate
Research output: Chapters, Conference Papers, Creative and Literary Works (RGC: 12, 32, 41, 45) › 32_Refereed conference paper (with ISBN/ISSN) › peer-review
Author(s)
Related Research Unit(s)
Detail(s)
| Original language | English |
|---|---|
| Title of host publication | Photons Plus Ultrasound |
| Subtitle of host publication | Imaging and Sensing 2021 |
| Editors | Alexander A. Oraevsky, Lihong V. Wang |
| Publisher | SPIE |
| ISBN (Electronic) | 9781510641204 |
| ISBN (Print) | 9781510641198 |
| Publication status | Published - 2021 |
Publication series
| Name | Progress in Biomedical Optics and Imaging - Proceedings of SPIE |
|---|---|
| Volume | 11642 |
| ISSN (Print) | 1605-7422 |
Conference
| Title | SPIE BiOS 2021 Digital Forum |
|---|---|
| Location | Online |
| Place | United States |
| City | California |
| Period | 6 - 11 March 2021 |
Link(s)
Abstract
We report wide-field polygon-scanning optical-resolution photoacoustic microscopy (OR-PAM) that achieves 1-MHz A-line rate of oxygen saturation in vivo. We develop a polygon-scanning imaging probe. Using stimulated Raman scattering and optical delay in fiber, we develop a dual-wavelength pulsed laser that has proper wavelengths, sufficient pulse energy, high pulse repetition rate, and sub-microseconds wavelength switching time for fast imaging of oxygen saturation. The OR-PAM system offers a 478-Hz B-scan rate and a 1-Hz volumetric imaging rate over a 12×5 mm2 scanning area. We demonstrate dynamic imaging of oxygen saturation of fast response to epinephrine injection in the mouse ear. Results show fast hemodynamic and functional changes in centimeter-sized areas.
Research Area(s)
- fast imaging, functional imaging, oxygen saturation, Photoacoustic microscopy, wide-field
Citation Format(s)
Wide-field photoacoustic microscopy of oxygen saturation at 1-MHz A-line rate. / Chen, Jiangbo; Zhang, Yachao; He, Linyun et al.
Photons Plus Ultrasound: Imaging and Sensing 2021. ed. / Alexander A. Oraevsky; Lihong V. Wang. SPIE, 2021. 116422U (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 11642).Research output: Chapters, Conference Papers, Creative and Literary Works (RGC: 12, 32, 41, 45) › 32_Refereed conference paper (with ISBN/ISSN) › peer-review
