Thermoresponsive drug delivery to mitochondria in vivo

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journal

2 Scopus Citations
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Author(s)

  • Lifo Ruan
  • Mengxue Zhou
  • Jun Chen
  • Hui Huang
  • Jiayu Zhang
  • Zhifang Chai
  • Yi Hu

Detail(s)

Original languageEnglish
Pages (from-to)14645-14648
Journal / PublicationChemical Communications
Volume55
Issue number97
Online published11 Nov 2019
Publication statusPublished - 18 Dec 2019

Abstract

Mitochondrial targeting of drugs largely relies on delocalized lipophilic cations. Nevertheless, mitochondrial membrane potentials in cancer cells are inconstant, which could compromise stable mitochondrial targeting. Herein, we further validated a mitochondrial temperature-dependent drug delivery strategy in vivo. Thermoresponsive drug delivery to mitochondria may represent a promising strategy for cancer therapy.

Citation Format(s)

Thermoresponsive drug delivery to mitochondria in vivo. / Ruan, Lifo; Zhou, Mengxue; Chen, Jun; Huang, Hui; Zhang, Jiayu; Sun, Hongyan; Chai, Zhifang; Hu, Yi.

In: Chemical Communications, Vol. 55, No. 97, 18.12.2019, p. 14645-14648.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journal