Ruthenium-indolizinone complexes as a new class of metalated heterocyclic compounds: insight into unconventional alkyne activation pathways, revelation of unexpected electronic properties and exploration of medicinal application

Lai-Hon Chung; Sze-Wing Ng; Chi-Fung Yeung; Hau-Lam Shek; Sheung-Ying Tse; Hoi-Shing Lo; Siu-Chung Chan; Man-Kit Tse; Shek-Man Yiu; Chun-Yuen Wong

doi:10.1039/c8dt02408a

Author(s)

Lai-Hon Chung
Sheung-Ying Tse
Siu-Chung Chan
Man-Kit Tse
Shek-Man Yiu

Related Research Unit(s)

Detail(s)

Original language	English
Pages (from-to)	12838-12842
Journal / Publication	Dalton Transactions
Volume	47
Issue number	37
Online published	5 Jul 2018
Publication status	Published - 7 Oct 2018

Link(s)

DOI	DOI https://doi.org/10.1039/c8dt02408a Final Published version
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Link to Scopus	https://www.scopus.com/record/display.uri?eid=2-s2.0-85053921335&origin=recordpage
Permanent Link	https://scholars.cityu.edu.hk/en/publications/publication(9abf6a17-efba-4eab-9855-95a890b2f40f).html

Abstract

The two series of ruthenium-indolizinone complexes prepared by Ru-mediated cyclization of pyridine-tethered alkynes represent the first examples of metalated indolizinone complexes. Joint experimental-theoretical investigation suggests an unconventional 5-endo-dig cyclization pathway as their formation mechanism. They also exhibit moderate cytotoxicity against several human cancer cell lines.

Citation Format(s)

[ RIS ] [ BibTeX ]

Ruthenium-indolizinone complexes as a new class of metalated heterocyclic compounds : insight into unconventional alkyne activation pathways, revelation of unexpected electronic properties and exploration of medicinal application. / Chung, Lai-Hon; Ng, Sze-Wing ; Yeung, Chi-Fung ; Shek, Hau-Lam; Tse, Sheung-Ying; Lo, Hoi-Shing; Chan, Siu-Chung; Tse, Man-Kit; Yiu, Shek-Man; Wong, Chun-Yuen.

In: Dalton Transactions, Vol. 47, No. 37, 07.10.2018, p. 12838-12842.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62) › 21_Publication in refereed journal › peer-review

Chung, L-H, Ng, S-W , Yeung, C-F , Shek, H-L, Tse, S-Y, Lo, H-S, Chan, S-C, Tse, M-K, Yiu, S-M & Wong, C-Y 2018, 'Ruthenium-indolizinone complexes as a new class of metalated heterocyclic compounds: insight into unconventional alkyne activation pathways, revelation of unexpected electronic properties and exploration of medicinal application', Dalton Transactions, vol. 47, no. 37, pp. 12838-12842. https://doi.org/10.1039/c8dt02408a

Chung, L-H., Ng, S-W., Yeung, C-F., Shek, H-L., Tse, S-Y., Lo, H-S., Chan, S-C., Tse, M-K., Yiu, S-M., & Wong, C-Y. (2018). Ruthenium-indolizinone complexes as a new class of metalated heterocyclic compounds: insight into unconventional alkyne activation pathways, revelation of unexpected electronic properties and exploration of medicinal application. Dalton Transactions, 47(37), 12838-12842. https://doi.org/10.1039/c8dt02408a

Chung L-H, Ng S-W , Yeung C-F , Shek H-L, Tse S-Y, Lo H-S et al. Ruthenium-indolizinone complexes as a new class of metalated heterocyclic compounds: insight into unconventional alkyne activation pathways, revelation of unexpected electronic properties and exploration of medicinal application. Dalton Transactions. 2018 Oct 7;47(37):12838-12842. https://doi.org/10.1039/c8dt02408a

Chung, Lai-Hon ; Ng, Sze-Wing ; Yeung, Chi-Fung ; Shek, Hau-Lam ; Tse, Sheung-Ying ; Lo, Hoi-Shing ; Chan, Siu-Chung ; Tse, Man-Kit ; Yiu, Shek-Man ; Wong, Chun-Yuen. / Ruthenium-indolizinone complexes as a new class of metalated heterocyclic compounds : insight into unconventional alkyne activation pathways, revelation of unexpected electronic properties and exploration of medicinal application. In: Dalton Transactions. 2018 ; Vol. 47, No. 37. pp. 12838-12842.

Ruthenium-indolizinone complexes as a new class of metalated heterocyclic compounds : insight into unconventional alkyne activation pathways, revelation of unexpected electronic properties and exploration of medicinal application