A metal-based inhibitor of tumor necrosis factor-α

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

157 Scopus Citations
Scopus Metrics
View graph of relations

Author(s)

  • Chung-Hang Leung
  • Hai-Jing Zhong
  • Hui Yang
  • Zhen Cheng
  • Daniel Shiu-Hin Chan
  • Victor Pui-Yan Ma
  • Ruben Abagyan
  • Dik-Lung Ma

Detail(s)

Original languageEnglish
Pages (from-to)9010-9014
Journal / PublicationAngewandte Chemie - International Edition
Volume51
Issue number36
Publication statusPublished - 3 Sept 2012

Link(s)

DOI

DOI
Check@CityULib
Link to Scopus https://www.scopus.com/record/display.uri?eid=2-s2.0-84865859280&origin=recordpage
Permanent Link https://scholars.cityu.edu.hk/en/publications/publication(985d7343-df49-4e7c-8a30-a4bf04e25385).html

Abstract

Staying in the pocket: A cyclometalated iridium(III) biquinoline complex targets the protein-protein interface (see picture; C yellow, N blue, Ir dark green) of the tumor necrosis factor-α (TNF-α) trimer. Molecular-modeling studies confirm the nature of this interaction. Both enantiomers of the iridium complex display comparable in vitro potency to the strongest small-molecule inhibitor of TNF-α. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Research Area(s)

  • inhibitors, iridium(III) complexes, metal-based inhibitors, protein-protein interactions, tumor necrosis factor

Fingerprint

Publication fingerprints text

100
Tumor Necrosis Fact... Keyphrases
100
Metal-based Inhibit... Keyphrases
100
Metal Medicine and Dentistry
100
Tumor Necrosis Fact... Medicine and Dentistry
100
metals INIS
100
tumor necrosis fact... INIS
66
Protein Medicine and Dentistry
66
proteins INIS
33
Copyright Keyphrases
33
Trimer Keyphrases
Full Fingerprint ›

Citation Format(s)

[ RIS ] [ BibTeX ]
A metal-based inhibitor of tumor necrosis factor-α. / Leung, Chung-Hang; Zhong, Hai-Jing; Yang, Hui et al.
In: Angewandte Chemie - International Edition, Vol. 51, No. 36, 03.09.2012, p. 9010-9014.

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review