Interactions between HIV-1 protease, silver nanoparticles, and specific peptides

Chieh-Hsuan Tsai; Chris G. Whiteley; Duu-Jong Lee

doi:10.1016/j.jtice.2019.07.019

Author(s)

Chieh-Hsuan Tsai
Chris G. Whiteley
Duu-Jong Lee

Detail(s)

Original language	English
Pages (from-to)	20-32
Journal / Publication	Journal of the Taiwan Institute of Chemical Engineers
Volume	103
Online published	9 Aug 2019
Publication status	Published - Oct 2019
Externally published	Yes

Link(s)

DOI	DOI https://doi.org/10.1016/j.jtice.2019.07.019 Final Published version
	Check@CityULib
Link to Scopus	https://www.scopus.com/record/display.uri?eid=2-s2.0-85070189460&origin=recordpage
Permanent Link	https://scholars.cityu.edu.hk/en/publications/publication(90e0f259-cdcd-43f2-b978-374395626bb9).html

Abstract

Use of silver nanoparticles (Ag NP's) as inhibitor for HIV-1 protease (PR) has practical interest. However, the interactions between the Ag NP's, HIV-1 PR, and the target peptides are not well demonstrated. This study experimentally revealed the interactions of the synthesized Ag NP's, HIV-1 PR, and five specific peptides with similar amino acid sequences to HIV's polyproteins. The Ag NP's can bind with either HIV-1 PR or the peptides. Incubating Ag NP's with peptide for 24 h can efficiently inhibit activity of HIV-1 PR. But HIV-1 PR would cleave peptides faster than the binding rate of Ag NP's and the peptides; therefore, late presence of Ag NP's would have no inhibition on the HIV-1 PR activity.