ZnL2-BPs Integrated Bone Scaffold under Sequential Photothermal Mediation : A Win-Win Strategy Delivering Antibacterial Therapy and Fostering Osteogenesis Thereafter

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review

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Author(s)

  • Qing Liao
  • Lie Wu
  • Yongxiang Luo
  • Wei Zhang
  • Min Guan
  • Haobo Pan
  • Liping Tong
  • Huaiyu Wang

Detail(s)

Original languageEnglish
Pages (from-to)17854–17869
Journal / PublicationACS Nano
Volume15
Issue number11
Online published27 Oct 2021
Publication statusPublished - 23 Nov 2021

Abstract

Implant-related infections are serious complications after bone surgery and can compromise the intended functions of artificial implants, leading to surgical failure and even amputation in severe cases. Various strategies have been proposed to endow bone implants with the desirable antibacterial properties, but unfortunately, most of them inevitably suffer from some side effects detrimental to normal tissues. In this study, a multifunctional bone implant is designed to work in conjunction with sequential photothermal mediation, which can deliver antibacterial therapy (<50 °C) in the early stage and foster bone regeneration (40-42 °C) subsequently. Black phosphorus nanosheets (BPs) are coordinated with zinc sulfonate ligand (ZnL2), and the ZnL2-BPs are integrated into the surface of a hydroxylapatite (HA) scaffold to produce ZnL2-BPs@HAP. In this design, BPs produce the photothermal effects and ZnL2 increases the thermal sensitivity of peri-implant bacteria by inducing envelope stress. The biosafety of the antibacterial photothermal treatment is improved due to the mild temperature, and furthermore, gradual release of Zn2+ and PO43- from the scaffold facilitates osteogenesis in the subsequent stage of bone healing. This strategy not only broadens the biomedical applications of photothermal treatment but also provides insights into the design of multifunctional biomaterials in other fields.

Research Area(s)

  • antibacterial therapy, bone implants, osteogenesis, sequential regulation, surface modification

Citation Format(s)

ZnL2-BPs Integrated Bone Scaffold under Sequential Photothermal Mediation: A Win-Win Strategy Delivering Antibacterial Therapy and Fostering Osteogenesis Thereafter. / Wu, Yuzheng; Liao, Qing; Wu, Lie et al.
In: ACS Nano, Vol. 15, No. 11, 23.11.2021, p. 17854–17869.

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review