Total synthesis and biological evaluation of (-)-englerin A and B: Synthesis of analogues with improved activity profile

Lea Radtke; Matthieu Willot; Hongyan Sun; Slava Ziegler; Stephanie Sauerland; Carsten Strohmann; Roland Fröhlich; Peter Habenberger; Herbert Waldmann; Mathias Christmann

doi:10.1002/anie.201007790

Total synthesis and biological evaluation of (-)-englerin A and B : Synthesis of analogues with improved activity profile

Research output: Journal Publications and Reviews (RGC: 21, 22, 62) › 21_Publication in refereed journal › peer-review

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Author(s)

Lea Radtke
Matthieu Willot
Slava Ziegler
Stephanie Sauerland
Carsten Strohmann
Roland Fröhlich
Peter Habenberger
Herbert Waldmann
Mathias Christmann

Detail(s)

Original language	English
Pages (from-to)	3998-4002
Journal / Publication	Angewandte Chemie - International Edition
Volume	50
Issue number	17
Publication status	Published - 18 Apr 2011
Externally published	Yes

Link(s)

DOI	DOI https://doi.org/10.1002/anie.201007790 Final Published version
	Check@CityULib
Link to Scopus	https://www.scopus.com/record/display.uri?eid=2-s2.0-79954576625&origin=recordpage
Permanent Link	https://scholars.cityu.edu.hk/en/publications/publication(8edad72a-21ea-453a-944b-c45a55e61a04).html

Abstract

The large-scale synthesis of englerin A (see scheme) and subsequent structure-activity relationship studies have led to the discovery of highly potent analogues. TBS=tert-butyldimethylsilyl. © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Research Area(s)

guaianes, renal cancer, structure-activity relationships, terpenes, total synthesis

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Citation Format(s)

[ RIS ] [ BibTeX ]

Total synthesis and biological evaluation of (-)-englerin A and B: Synthesis of analogues with improved activity profile. / Radtke, Lea; Willot, Matthieu; Sun, Hongyan et al.
In: Angewandte Chemie - International Edition, Vol. 50, No. 17, 18.04.2011, p. 3998-4002.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62) › 21_Publication in refereed journal › peer-review

Radtke, L, Willot, M, Sun, H, Ziegler, S, Sauerland, S, Strohmann, C, Fröhlich, R, Habenberger, P, Waldmann, H & Christmann, M 2011, 'Total synthesis and biological evaluation of (-)-englerin A and B: Synthesis of analogues with improved activity profile', Angewandte Chemie - International Edition, vol. 50, no. 17, pp. 3998-4002. https://doi.org/10.1002/anie.201007790

Radtke, L., Willot, M., Sun, H., Ziegler, S., Sauerland, S., Strohmann, C., Fröhlich, R., Habenberger, P., Waldmann, H., & Christmann, M. (2011). Total synthesis and biological evaluation of (-)-englerin A and B: Synthesis of analogues with improved activity profile. Angewandte Chemie - International Edition, 50(17), 3998-4002. https://doi.org/10.1002/anie.201007790

Radtke L, Willot M, Sun H, Ziegler S, Sauerland S, Strohmann C et al. Total synthesis and biological evaluation of (-)-englerin A and B: Synthesis of analogues with improved activity profile. Angewandte Chemie - International Edition. 2011 Apr 18;50(17):3998-4002. doi: 10.1002/anie.201007790

Radtke, Lea ; Willot, Matthieu ; Sun, Hongyan et al. / Total synthesis and biological evaluation of (-)-englerin A and B : Synthesis of analogues with improved activity profile. In: Angewandte Chemie - International Edition. 2011 ; Vol. 50, No. 17. pp. 3998-4002.