Expression of two novel mouse Iroquois homeobox genes during neurogenesis

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review

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Author(s)

Detail(s)

Original languageEnglish
Pages (from-to)317-321
Journal / PublicationMechanisms of Development
Volume91
Issue number1-2
Publication statusPublished - 1 Mar 2000

Abstract

Members of the Drosophila Iroquois homeobox gene family are implicated in the development of peripheral nervous system and the regionalization of wing and eye imaginal discs. Recent studies suggest that Xenopus Iroquois homeobox (Irx) genes are also involved in neurogenesis. Three mouse Irx genes, Irx1, Irx2 and Irx3, have been previously identified and are expressed with distinct spatio-temporal patterns during neurogenesis. We report here the cloning and expression analysis of two novel mouse Irx genes, Irx5 and Irx6. Although Irx5 and Irx6 proteins are structurally more related to one another, we find that Irx5 displays a developmental expression pattern strikingly similar to that of Irx3, whereas Irx6 expression resembles that of Irx1. Consistent with the notion that Mash1 is a putative target gene of the Irx proteins, all four Irx genes display an overlapping expression pattern with Mash1 in the developing CNS. In contrast, the Irx genes and Mash1 are expressed in complementary domains in the developing eye and olfactory epithelium. (C) 2000 Elsevier Science Ireland Ltd.

Research Area(s)

  • Achaete-scute complex, Brachial arch, Eye, Foregut, Heart, Hindbrain, Homeobox genes, Iroquois gene complex (IRO-C), Limb, Mash1, Midbrain, Neural retina, Olfactory epithelium, Respiratory epithelium, Spinal cord

Citation Format(s)

Expression of two novel mouse Iroquois homeobox genes during neurogenesis. / Cohen, Dana R.; Cheng, Chi Wa; Cheng, Shuk Han et al.
In: Mechanisms of Development, Vol. 91, No. 1-2, 01.03.2000, p. 317-321.

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review