RutheniumII(η6-arene) Complexes of Thiourea Derivatives : Synthesis, Characterization and Urease Inhibition

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

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  • Muhammad Hanif
  • Muhammad Azhar Hayat Nawaz
  • Jamshed Iqbal
  • Alexander Roller
  • Bernhard K. Keppler
  • Christian G. Hartinger


Original languageEnglish
Pages (from-to)8080-8092
Journal / PublicationMolecules
Issue number6
Online published16 Jun 2014
Publication statusPublished - Jun 2014
Externally publishedYes



RuII(arene) complexes have emerged as a versatile class of compounds to design metallodrugs as potential treatment for a wide range of diseases including cancer and malaria. They feature modes of action that involve classic DNA binding like platinum anticancer drugs, may covalent binding to proteins, or multimodal biological activity. Herein, we report the synthesis and urease inhibition activity of RuII(arene) complexes of the general formula [RuII(η6-p-cymene)(L)Cl2] and [RuII(η6-p-cymene)(PPh3)(L)Cl]PF6 with S-donor systems (L) based on heterocyclic thiourea derivatives. The compounds were characterized by 1H-, 13C{1H}- and 31P{1H}-NMR spectroscopy, as well as elemental analysis. The crystal structure of [chlorido(η6-p-cymene)(imidazolidine-2-thione) (triphenylphosphine)ruthenium(II)] hexafluorophosphate 11 was determined by X-ray diffraction analysis. A signal in the range 175.183 ppm in the 13C{1H}-NMR spectrum indicates the presence of a thione rather than a thiolate. This observation was also confirmed in the solid state by X-ray diffraction analysis of 11 which shows a C=S bond length of 1.720 Å. The compounds were tested for urease inhibitory activity and the thiourea-derived ligands exhibited moderate activity, whereas their corresponding Ru(arene) complexes were not active. © 2014 by the authors.

Research Area(s)

  • Ru(arene) complexes, Thiourea, Triphenylphosphine, Urease inhibition

Citation Format(s)

RutheniumII(η6-arene) Complexes of Thiourea Derivatives: Synthesis, Characterization and Urease Inhibition. / Hanif, Muhammad; Nawaz, Muhammad Azhar Hayat; Babak, Maria V. et al.
In: Molecules, Vol. 19, No. 6, 06.2014, p. 8080-8092.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

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