A highly versatile platform based on geometrically well-defined 3D DNA nanostructures for selective recognition and positioning of multiplex targets

Ziwen Dai; Qi Gao; Man Ching Cheung; Hoi Man Leung; Terrence Chi Kong Lau; Hanadi F. Sleiman; King Wai Chiu Lai; Pik Kwan Lo

doi:10.1039/c6nr05411k

Author(s)

Qi Gao
Man Ching Cheung
Hoi Man Leung
Hanadi F. Sleiman

Related Research Unit(s)

Department of Mechanical and Biomedical Engineering
Department of Biomedical Sciences

Detail(s)

Original language	English
Pages (from-to)	18291-18295
Journal / Publication	Nanoscale
Volume	8
Issue number	43
Publication status	Published - 21 Nov 2016

Link(s)

DOI	DOI https://doi.org/10.1039/c6nr05411k Final Published version
	Check@CityULib
Link to Scopus	https://www.scopus.com/record/display.uri?eid=2-s2.0-84994626527&origin=recordpage
Permanent Link	https://scholars.cityu.edu.hk/en/publications/publication(70fac36f-615b-4735-b2ea-a521880716fa).html

Abstract

We develop a versatile recognition system based on 3D triangular-shaped DNA nanotubes by integrating three different aptamer sequences along the three edges. This would allow multiple binding activities to be combined into a single system. The versatility of this nanotube platform can also provide a framework for spatial orientation and positioning of different aptamer-binding ligands in a 'pea-pod' architecture.

Citation Format(s)

[ RIS ] [ BibTeX ]

A highly versatile platform based on geometrically well-defined 3D DNA nanostructures for selective recognition and positioning of multiplex targets. / Dai, Ziwen; Gao, Qi; Cheung, Man Ching; Leung, Hoi Man; Lau, Terrence Chi Kong; Sleiman, Hanadi F.; Lai, King Wai Chiu ; Lo, Pik Kwan.

In: Nanoscale, Vol. 8, No. 43, 21.11.2016, p. 18291-18295.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62) › 21_Publication in refereed journal › peer-review

Dai, Z, Gao, Q, Cheung, MC, Leung, HM, Lau, TCK, Sleiman, HF, Lai, KWC & Lo, PK 2016, 'A highly versatile platform based on geometrically well-defined 3D DNA nanostructures for selective recognition and positioning of multiplex targets', Nanoscale, vol. 8, no. 43, pp. 18291-18295. https://doi.org/10.1039/c6nr05411k

Dai, Z., Gao, Q., Cheung, M. C., Leung, H. M., Lau, T. C. K., Sleiman, H. F., Lai, K. W. C., & Lo, P. K. (2016). A highly versatile platform based on geometrically well-defined 3D DNA nanostructures for selective recognition and positioning of multiplex targets. Nanoscale, 8(43), 18291-18295. https://doi.org/10.1039/c6nr05411k

Dai Z, Gao Q, Cheung MC, Leung HM, Lau TCK, Sleiman HF et al. A highly versatile platform based on geometrically well-defined 3D DNA nanostructures for selective recognition and positioning of multiplex targets. Nanoscale. 2016 Nov 21;8(43):18291-18295. https://doi.org/10.1039/c6nr05411k

Dai, Ziwen ; Gao, Qi ; Cheung, Man Ching ; Leung, Hoi Man ; Lau, Terrence Chi Kong ; Sleiman, Hanadi F. ; Lai, King Wai Chiu ; Lo, Pik Kwan. / A highly versatile platform based on geometrically well-defined 3D DNA nanostructures for selective recognition and positioning of multiplex targets. In: Nanoscale. 2016 ; Vol. 8, No. 43. pp. 18291-18295.