Tuning the surface immunomodulatory functions of polyetheretherketone for enhanced osseointegration

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journal

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Author(s)

  • Qing Liao
  • Lingxia Xie
  • Wei Zhang
  • Yuzheng Wu
  • Penghui Li
  • Min Guan
  • Haobo Pan
  • Liping Tong
  • Huaiyu Wang

Detail(s)

Original languageEnglish
Article number119642
Journal / PublicationBiomaterials
Volume230
Online published20 Nov 2019
Publication statusPublished - Feb 2020

Abstract

The adverse macrophage-mediated immune response elicited by the surface of polyetheretherketone (PEEK) is responsible for the formation of fibrous encapsulation and resulting inferior osseointegration of PEEK implants in the dental and orthopedic fields. Therefore, endowing the PEEK surface with immunomodulatory ability is an appealing strategy to enhance implant-bone integration. Herein, a reliable and cost-effective method to construct adherent films with tunable nanoporous structures on PEEK is described. The functionalized surface not only suppresses the acute inflammatory response of macrophages, but also provides a favorable milieu for osteogenic differentiation of human bone marrow mesenchymal stem cells (hBMSCs). Whole genome expression analysis reveals that the suppression effect arises from synergistic inhibition of focal adhesion, Toll-like receptor, and NOD-like receptor signaling pathways, as well as the attenuating loop through the JAK-STAT and TNF signaling pathways in macrophages. Further in vivo studies confirm that the functionalized surface induces less fibrous capsule formation and an improved bone regeneration. The nanoporous films fabricated on PEEK harmonize the early macrophage-mediated inflammatory response and subsequent hBMSCs-centered osteogenic functions consequently yielding superior osseointegration.

Research Area(s)

  • Immunomodulation, Orthopedic implants, Osseointegration, Polyetheretherketone, Surface modification

Citation Format(s)

Tuning the surface immunomodulatory functions of polyetheretherketone for enhanced osseointegration. / Gao, Ang; Liao, Qing; Xie, Lingxia; Wang, Guomin; Zhang, Wei; Wu, Yuzheng; Li, Penghui; Guan, Min; Pan, Haobo; Tong, Liping; Chu, Paul K.; Wang, Huaiyu.

In: Biomaterials, Vol. 230, 119642, 02.2020.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journal