Low Prevalence of SARS-CoV-2 Antibodies in Canine and Feline Serum Samples Collected during the COVID-19 Pandemic in Hong Kong and Korea

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

3 Scopus Citations
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Author(s)

  • Maura Carrai
  • Yan Ru Choi
  • Christopher J. Brackman
  • Karina W. S. Tam
  • Pierra Y. T. Law
  • Fiona Woodhouse
  • Jane Gray
  • Ji Hun Kim
  • Joohyung Park
  • Chae Won Jeon
  • Hyomi Jang
  • Nicola Decaro
  • Samuel M.S. Cheng
  • Malik Peiris

Detail(s)

Original languageEnglish
Article number582
Journal / PublicationViruses
Volume15
Issue number2
Online published20 Feb 2023
Publication statusPublished - Feb 2023

Link(s)

Abstract

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has affected millions of people worldwide since its emergence in 2019. Knowing the potential capacity of the virus to adapt to other species, the serological surveillance of SARS-CoV-2 infection in susceptible animals is important. Hong Kong and Seoul are two of Asia’s most densely populated urban cities, where companion animals often live in close contact with humans. Sera collected from 1040 cats and 855 dogs during the early phase of the pandemic in Hong Kong and Seoul were tested for SARS-CoV-2 antibodies using an ELISA that detects antibodies against the receptor binding domain of the viral spike protein. Positive sera were also tested for virus neutralizing antibodies using a surrogate virus neutralization (sVNT) and plaque reduction neutralization test (PRNT). Among feline sera, 4.51% and 2.54% of the samples from Korea and Hong Kong, respectively, tested ELISA positive. However, only 1.64% of the samples from Korea and 0.18% from Hong Kong tested positive by sVNT, while only 0.41% of samples from Korea tested positive by PRNT. Among canine samples, 4.94% and 6.46% from Korea and Hong Kong, respectively, tested positive by ELISA, while only 0.29% of sera from Korea were positive on sVNT and no canine sera tested positive by PRNT. These results confirm a low seroprevalence of SARS-CoV-2 exposure in companion animals in Korea and Hong Kong. The discordance between the RBD-ELISA and neutralization tests may indicate possible ELISA cross-reactivity with other coronaviruses, especially in canine sera. © 2023 by the authors.

Research Area(s)

  • canine, COVID-19, feline, SARS-CoV-2, seroprevalence, zoonosis

Citation Format(s)

Low Prevalence of SARS-CoV-2 Antibodies in Canine and Feline Serum Samples Collected during the COVID-19 Pandemic in Hong Kong and Korea. / Go, Yun Young; Carrai, Maura; Choi, Yan Ru et al.
In: Viruses, Vol. 15, No. 2, 582, 02.2023.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

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