Protocol to analyze population structure and migration history based on human genome variation data

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

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Original languageEnglish
Article number101928
Journal / PublicationSTAR Protocols
Issue number1
Online published13 Dec 2022
Publication statusPublished - 17 Mar 2023



We describe a protocol to integrate genome variation data from different datasets and explore the population structure and migration history of human populations. This protocol provides semi-automated scripts to perform and visualize the effect of variant filtering strategy on eliminating batch effects, principal component analysis, ancestry component analysis, historical population effective size inference, and migration and isolation analysis based on independent biallelic SNPs, genotype likelihoods, and haplotypes. The protocol can be adapted to variation data from other sources. 

Research Area(s)

  • Bioinformatics, Computer sciences, Evolutionary biology, Genomics

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