A Double-Layered Microneedle Platform Fabricated through Frozen Spray-Coating

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

22 Scopus Citations
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Author(s)

  • Xiaoyu Ning
  • Christian Wiraja
  • Daniel Chin Shiuan Lio
  • Chenjie Xu

Related Research Unit(s)

Detail(s)

Original languageEnglish
Article number2000147
Journal / PublicationAdvanced Healthcare Materials
Volume9
Issue number10
Online published22 Apr 2020
Publication statusPublished - 20 May 2020

Abstract

This work reports a frozen spray-coating method for the fabrication of double-layered microneedles (MNs). Taking swellable methacrylated hyaluronic acid (MeHA)-derived MNs as the model, both hydrophobic molecules (Nile red, Cy5) and hydrophilic ones (FITC, FITC-Dextran, Insulin) can be homogeneously coated without impacting the mechanical properties of the original MeHA MNs. The prepared double-layered MNs can execute multiple roles. It is demonstrated that insulin-coated MeHA double-layered MNs allow the effective delivery of the insulin into circulation of mice for controlling the blood glucose level while they also permit the extraction of skin interstitial fluid for the timely analysis of the biomarker (glucose).

Research Area(s)

  • double-layered microneedles, frozen spray-coating, interstitial skin fluid extraction, transdermal drug delivery

Citation Format(s)

A Double-Layered Microneedle Platform Fabricated through Frozen Spray-Coating. / Ning, Xiaoyu; Wiraja, Christian; Lio, Daniel Chin Shiuan; Xu, Chenjie.

In: Advanced Healthcare Materials, Vol. 9, No. 10, 2000147, 20.05.2020.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review