A Circuit for Gradient Climbing in C. elegans Chemotaxis

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review

92 Scopus Citations
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Author(s)

  • Johannes Larsch
  • Steven W. Flavell
  • Andrew Gordus
  • Dirk R. Albrecht
  • Cornelia I. Bargmann

Detail(s)

Original languageEnglish
Pages (from-to)1748-1760
Journal / PublicationCell Reports
Volume12
Issue number11
Publication statusPublished - 22 Sept 2015
Externally publishedYes

Link(s)

Abstract

Animals have a remarkable ability to track dynamic sensory information. For example, the nematode Caenorhabditis elegans can locate a diacetyl odor source across a 100,000-fold concentration range. Here, we relate neuronal properties, circuit implementation, and behavioral strategies underlying this robust navigation. Diacetyl responses in AWA olfactory neurons are concentration and history dependent; AWA integrates over time at low odor concentrations, but as concentrations rise, it desensitizes rapidly through a process requiring cilia transport. After desensitization, AWA retains sensitivity to small odor increases. The downstream AIA interneuron amplifies weak odor inputs and desensitizes further, resulting in a stereotyped response to odor increases over three orders of magnitude. The AWA-AIA circuit drives asymmetric behavioral responses to odor increases that facilitate gradient climbing. The adaptation-based circuit motif embodied by AWA and AIA shares computational properties with bacterial chemotaxis and the vertebrate retina, each providing a solution for maintaining sensitivity across a dynamic range.

Research Area(s)

Bibliographic Note

Publication details (e.g. title, author(s), publication statuses and dates) are captured on an “AS IS” and “AS AVAILABLE” basis at the time of record harvesting from the data source. Suggestions for further amendments or supplementary information can be sent to lbscholars@cityu.edu.hk.

Citation Format(s)

A Circuit for Gradient Climbing in C. elegans Chemotaxis. / Larsch, Johannes; Flavell, Steven W.; Liu, Qiang et al.
In: Cell Reports, Vol. 12, No. 11, 22.09.2015, p. 1748-1760.

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review

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