On statistical tests for homogeneity of two bivariate zero-inflated poisson populations
Research output: Journal Publications and Reviews (RGC: 21, 22, 62) › 21_Publication in refereed journal › peer-review
Author(s)
Related Research Unit(s)
Detail(s)
| Original language | English |
|---|---|
| Pages (from-to) | 44-53 |
| Journal / Publication | Journal of Biopharmaceutical Statistics |
| Volume | 25 |
| Issue number | 1 |
| Online published | 20 Jan 2015 |
| Publication status | Published - 2015 |
Link(s)
Abstract
The problem of testing treatment difference in the occurrence of a study endpoint in a randomized parallel-group comparative clinical trial with repeated responses under the assumption that the responses follow a bivariate zero-inflated Poisson (ZIP) distribution is considered. Likelihood ratio test for homogeneity of two bivariate ZIP populations is derived. Approximate formula for sample size calculation is also obtained, which achieves a desired power for detecting a clinically meaningful difference under an alternative hypothesis. An example concerning the comparison of treatment effect in an addictive clinical trial in terms of the number of days of illicit drug use during a month is given for illustrative purposes.
Research Area(s)
- Erosion counts, Likelihood ratio test, Sample size calculation, Zero-inflated poisson distribution
Citation Format(s)
On statistical tests for homogeneity of two bivariate zero-inflated poisson populations. / Yuen, Hak-Keung; Chow, Shein-Chung; Tse, Siu-Keung.
In: Journal of Biopharmaceutical Statistics, Vol. 25, No. 1, 2015, p. 44-53.Research output: Journal Publications and Reviews (RGC: 21, 22, 62) › 21_Publication in refereed journal › peer-review
