Host-pathogen interaction in arthropod vectors : Lessons from viral infections

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review

5 Scopus Citations
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Author(s)

  • Nighat Perveen
  • Khalid Muhammad
  • Sabir Bin Muzaffar
  • Tean Zaheer
  • Nayla Munawar
  • Bojan Gajic
  • Uday Kishore
  • Arve Lee Willingham

Detail(s)

Original languageEnglish
Article number1061899
Journal / PublicationFrontiers in Immunology
Volume14
Online published31 Jan 2023
Publication statusPublished - 2023

Link(s)

Abstract

Haematophagous arthropods can harbor various pathogens including viruses, bacteria, protozoa, and nematodes. Insects possess an innate immune system comprising of both cellular and humoral components to fight against various infections. Haemocytes, the cellular components of haemolymph, are central to the insect immune system as their primary functions include phagocytosis, encapsulation, coagulation, detoxification, and storage and distribution of nutritive materials. Plasmatocytes and granulocytes are also involved in cellular defense responses. Blood-feeding arthropods, such as mosquitoes and ticks, can harbour a variety of viral pathogens that can cause infectious diseases in both human and animal hosts. Therefore, it is imperative to study the virus-vector-host relationships since arthropod vectors are important constituents of the ecosystem. Regardless of the complex immune response of these arthropod vectors, the viruses usually manage to survive and are transmitted to the eventual host. A multidisciplinary approach utilizing novel and strategic interventions is required to control ectoparasite infestations and block vector-borne transmission of viral pathogens to humans and animals. In this review, we discuss the arthropod immune response to viral infections with a primary focus on the innate immune responses of ticks and mosquitoes. We aim to summarize critically the vector immune system and their infection transmission strategies to mammalian hosts to foster debate that could help in developing new therapeutic strategies to protect human and animal hosts against arthropod-borne viral infections. Copyright © 2023 Perveen, Muhammad, Muzaffar, Zaheer, Munawar, Gajic, Sparagano, Kishore and Willingham.

Research Area(s)

  • antiviral defense, haemocoel, haemocytes, immune system, innate immunity, virus circulation

Citation Format(s)

Host-pathogen interaction in arthropod vectors: Lessons from viral infections. / Perveen, Nighat; Muhammad, Khalid; Muzaffar, Sabir Bin et al.
In: Frontiers in Immunology, Vol. 14, 1061899, 2023.

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review

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