Hydride Reduction by a Sodium Hydride-Iodide Composite
Research output: Journal Publications and Reviews (RGC: 21, 22, 62) › 21_Publication in refereed journal › peer-review
Author(s)
Detail(s)
| Original language | English |
|---|---|
| Pages (from-to) | 3719-3723 |
| Journal / Publication | Angewandte Chemie - International Edition |
| Volume | 55 |
| Issue number | 11 |
| Publication status | Published - 7 Mar 2016 |
| Externally published | Yes |
Link(s)
| DOI | DOI |
|---|---|
| Attachment(s) | Documents
Publisher's Copyright Statement
|
| Link to Scopus | https://www.scopus.com/record/display.uri?eid=2-s2.0-84976246970&origin=recordpage |
| Permanent Link | https://scholars.cityu.edu.hk/en/publications/publication(525dca69-6f92-4313-959e-db52f252dd06).html |
Abstract
Sodium hydride (NaH) is widely used as a Brønsted base in chemical synthesis and reacts with various Brønsted acids, whereas it rarely behaves as a reducing reagent through delivery of the hydride to polar π electrophiles. This study presents a series of reduction reactions of nitriles, amides, and imines as enabled by NaH in the presence of LiI or NaI. This remarkably simple protocol endows NaH with unprecedented and unique hydride-donor chemical reactivity.
Research Area(s)
- amides, decyanation, density functional calculations, reduction, sodium hydride
Citation Format(s)
Hydride Reduction by a Sodium Hydride-Iodide Composite. / Too, Pei Chui; Chan, Guo Hao; Tnay, Ya Lin et al.
In: Angewandte Chemie - International Edition, Vol. 55, No. 11, 07.03.2016, p. 3719-3723.
In: Angewandte Chemie - International Edition, Vol. 55, No. 11, 07.03.2016, p. 3719-3723.
Research output: Journal Publications and Reviews (RGC: 21, 22, 62) › 21_Publication in refereed journal › peer-review
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