Genetic and Functional Characterization of blaCTX-M-199, a Novel Tazobactam and Sulbactam Resistance-Encoding Gene Located in a Conjugative mcr-1-Bearing IncI2 Plasmid
Research output: Journal Publications and Reviews (RGC: 21, 22, 62) › 21_Publication in refereed journal › peer-review
Author(s)
Detail(s)
Original language | English |
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Article number | e00562-17 |
Journal / Publication | Antimicrobial Agents and Chemotherapy |
Volume | 61 |
Issue number | 7 |
Online published | 8 May 2017 |
Publication status | Published - Jul 2017 |
Externally published | Yes |
Link(s)
Abstract
We report the genetic and functional characterization of a novel CTX-M-199 β-lactamase, which was encoded by a blaCTX-M-64 variant gene found in a conjugative mcr-1-bearing IncI2 plasmid and exhibited resistance to β-lactamase inhibitors, tazobactam, and sulbactam.
Research Area(s)
- Conjugative IncI2 plasmid, CTX-M-199, Enzyme kinetics, Function, Inhibitor resistance, mcr-1
Citation Format(s)
Genetic and Functional Characterization of blaCTX-M-199, a Novel Tazobactam and Sulbactam Resistance-Encoding Gene Located in a Conjugative mcr-1-Bearing IncI2 Plasmid. / Cai, Jiachang; Cheng, Qipeng; Shen, Yingbo; Gu, Danxia; Fang, Ying; Chan, Edward Wai-Chi; Chen, Sheng.
In: Antimicrobial Agents and Chemotherapy, Vol. 61, No. 7, e00562-17, 07.2017.Research output: Journal Publications and Reviews (RGC: 21, 22, 62) › 21_Publication in refereed journal › peer-review