Tau PTM Profiles Identify Patient Heterogeneity and Stages of Alzheimer's Disease

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

47 Scopus Citations
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Author(s)

  • Hendrik Wesseling
  • Waltraud Mair
  • Mukesh Kumar
  • Christoph N. Schlaffner
  • Pieter Beerepoot
  • Benoit Fatou
  • Amanda J. Guise
  • Long Cheng
  • Shuko Takeda
  • Jan Muntel
  • Melissa S. Rotunno
  • Simon Dujardin
  • Peter Davies
  • Kenneth S. Kosik
  • Bruce L. Miller
  • Sabina Berretta
  • John C. Hedreen
  • Lea T. Grinberg
  • William W. Seeley
  • Bradley T. Hyman
  • Hanno Steen
  • Judith A. Steen

Detail(s)

Original languageEnglish
Article numbere13
Pages (from-to)1699-1713
Journal / PublicationCell
Volume183
Issue number6
Online published13 Nov 2020
Publication statusPublished - 10 Dec 2020
Externally publishedYes

Abstract

A high-resolution quantitative proteomics map of post-translational modifications on multiple isoforms of Tau shows heterogeneity across Alzheimer's disease patients, reflective of disease progression, and identifies critical targets at each stage of disease.

Research Area(s)

  • absolute quantification, disease progression, FLEXITau, multiple reaction monitoring (MRM), post-translational modifications, prion-like molecules, protein aggregation, proteomics, proteopathy, quantitative mass spectrometry

Citation Format(s)

Tau PTM Profiles Identify Patient Heterogeneity and Stages of Alzheimer's Disease. / Wesseling, Hendrik; Mair, Waltraud; Kumar, Mukesh; Schlaffner, Christoph N.; Tang, Shaojun; Beerepoot, Pieter; Fatou, Benoit; Guise, Amanda J.; Cheng, Long; Takeda, Shuko; Muntel, Jan; Rotunno, Melissa S.; Dujardin, Simon; Davies, Peter; Kosik, Kenneth S.; Miller, Bruce L.; Berretta, Sabina; Hedreen, John C.; Grinberg, Lea T.; Seeley, William W.; Hyman, Bradley T.; Steen, Hanno; Steen, Judith A.

In: Cell, Vol. 183, No. 6, e13, 10.12.2020, p. 1699-1713.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review