Hormetic effect induced by depleted uranium in zebrafish embryos
Related Research Unit(s)
|Journal / Publication||Aquatic Toxicology|
|Online published||29 Mar 2016|
|Publication status||Published - Jun 2016|
|Link to Scopus||https://www.scopus.com/record/display.uri?eid=2-s2.0-84962663468&origin=recordpage|
The present work studied the hormetic effect induced by uranium (U) in embryos of zebrafish (Danio rerio) using apoptosis as the biological endpoint. Hormetic effect is characterized by biphasic dose-response relationships showing a low-dose stimulation and a high-dose inhibition. Embryos were dechorionated at 4 h post fertilization (hpf), and were then exposed to 10 or 100 μg/l depleted uranium (DU) in uranyl acetate solutions from 5 to 6 hpf. For exposures to 10 μg/l DU, the amounts of apoptotic signals in the embryos were significantly increased at 20 hpf but were significantly decreased at 24 hpf, which demonstrated the presence of U-induced hormesis. For exposures to 100 μg/l DU, the amounts of apoptotic signals in the embryos were significantly increased at 20, 24 and 30 hpf. Hormetic effect was not shown but its occurrence between 30 and 48 hpf could not be ruled out. In conclusion, hormetic effect could be induced in zebrafish embryos in a concentration- and time-dependent manner.
- Uranium, Depleted uranium, Hormetic effect, Zebrafish embryo
Aquatic Toxicology, Vol. 175, 06.2016, p. 184-191.
Research output: Journal Publications and Reviews (RGC: 21, 22, 62) › 21_Publication in refereed journal
Ng, CYP, Cheng, SH & Yu, KN 2016, 'Hormetic effect induced by depleted uranium in zebrafish embryos', Aquatic Toxicology, vol. 175, pp. 184-191. https://doi.org/10.1016/j.aquatox.2016.03.020
Ng, C. Y. P., Cheng, S. H., & Yu, K. N. (2016). Hormetic effect induced by depleted uranium in zebrafish embryos. Aquatic Toxicology, 175, 184-191. https://doi.org/10.1016/j.aquatox.2016.03.020