Cytochrome p450 2E1 polymorphisms and the risk of gastric cardia cancer

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journal

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Author(s)

Detail(s)

Original languageEnglish
Pages (from-to)1867-1871
Journal / PublicationWorld Journal of Gastroenterology
Volume11
Issue number12
Publication statusPublished - 28 Mar 2005
Externally publishedYes

Abstract

Aim: Genetic polymorphisms of drug-metabolizing enzymes have recently been shown to affect susceptibility to chemical carcinogenesis. Cytochrome P450 2E1 (CYP2E1) enzyme catalyzes the metabolism of many procarcinogens, such as N-nitrosamines and related compounds. The gene coding for this enzyme is polymorphic and thus may play a role in gastric cardia cancer (GCC) etiology. In this hospital-based case-control study, we evaluate the relationship between genetic polymorphisms of CYP2E1 and the risk of GCC. Methods: The study subjects comprised 159 histologically confirmed GCC cases identified via hospital cancer registry and surgical records at five hospitals in Fuzhou, Fujian Province, China, between April and November 2001. Controls were 192 patients admitted to the same hospitals for nonmalignant conditions. The genotypes of CYP2E1 were detected by a PCR-based RFLP assay. The odds ratios were estimated by logistic regression analyses and were adjusted for potential confounding factors. Results: The distribution of three genotypes of CYP2E1 in GCC cases and controls was significantly different (χ2 = 16.04, P

Research Area(s)

  • Cardia cancer, CYP2E1, Genetic susceptibility

Citation Format(s)

Cytochrome p450 2E1 polymorphisms and the risk of gastric cardia cancer. / Cai, Lin; Zheng, Zong-Li; Zhang, Zuo-Feng.

In: World Journal of Gastroenterology, Vol. 11, No. 12, 28.03.2005, p. 1867-1871.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journal