Virtual adult ears reveal the roles of acoustical factors and experience in auditory space map development

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journal

21 Scopus Citations
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Author(s)

  • Robert A. A. Campbell
  • Andrew J. King
  • Fernando R. Nodal
  • Simon Carlile
  • Timothy P. Doubell

Detail(s)

Original languageEnglish
Pages (from-to)11557-11570
Journal / PublicationJournal of Neuroscience
Volume28
Issue number45
Publication statusPublished - 5 Nov 2008
Externally publishedYes

Abstract

Auditory neurons in the superior colliculus (SC) respond preferentially to sounds from restricted directions to form a map of auditory space. The development of this representation is shaped by sensory experience, but little is known about the relative contribution of peripheral and central factors to the emergence of adult responses. By recording from the SC of anesthetized ferrets at different age points, we show that the map matures gradually after birth; the spatial receptive fields (SRFs) become more sharply tuned and topographic order emerges by the end of the second postnatal month. Principal components analysis of the head-related transfer function revealed that the time course of map development is mirrored by the maturation of the spatial cues generated by the growing head and external ears. However, using virtual acoustic space stimuli, we show that these acoustical changes are not by themselves responsible for the emergence of SC map topography. Presenting stimuli to infant ferrets through virtual adult ears did not improve the order in the representation of sound azimuth in the SC. But by using linear discriminant analysis to compare different response properties across age, we found that the SRFs of infant neurons nevertheless became more adult-like when stimuli were delivered through virtual adult ears. Hence, although the emergence of auditory topography is likely to depend on refinements in neural circuitry, maturation of the structure of the SRFs (particularly their spatial extent) can be largely accounted for by changes in the acoustics associated with growth of the head and ears. Copyright © 2008 Society for Neuroscience.

Research Area(s)

  • Ferret, Head-related transfer function, Linear discriminant analysis, Receptive field, Sound localization, Virtual acoustic space

Citation Format(s)

Virtual adult ears reveal the roles of acoustical factors and experience in auditory space map development. / Campbell, Robert A. A.; King, Andrew J.; Nodal, Fernando R.; Schnupp, Jan W. H.; Carlile, Simon; Doubell, Timothy P.

In: Journal of Neuroscience, Vol. 28, No. 45, 05.11.2008, p. 11557-11570.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journal