Photoactivatable cytotoxic agents derived from mitochondria-targeting luminescent iridium(III) poly(ethylene glycol) complexes modified with a nitrobenzyl linkage

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

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Detail(s)

Original languageEnglish
Pages (from-to)4557-4560
Journal / PublicationChemical Communications
Volume52
Issue number24
Online published24 Feb 2016
Publication statusPublished - 25 Mar 2016

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DOI

DOI
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Link to Scopus https://www.scopus.com/record/display.uri?eid=2-s2.0-84961267125&origin=recordpage
Permanent Link https://scholars.cityu.edu.hk/en/publications/publication(31ffe758-e0c1-46de-9764-eb6393e10f32).html

Abstract

Two novel photoactivatable mitochondria-targeting luminescent iridium(iii) poly(ethylene glycol) (PEG) complexes incorporated with a nitrobenzyl group were designed. They showed minimal cytotoxic activity in the dark, but became significantly cytotoxic upon irradiation due to the release of the PEG pendants.

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Publication fingerprints text

100
Luminiscence Type Chemistry
100
Cytotoxic Agent Chemistry
100
Iridium Chemistry
100
Poly(ethylene Glyco... Chemistry
100
luminescence INIS
100
polyethylene glycol... INIS
100
mitochondria INIS
100
iridium INIS
100
Polyethylene Glycol Keyphrases
100
O-nitrobenzyl Keyphrases
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Citation Format(s)

[ RIS ] [ BibTeX ]
Photoactivatable cytotoxic agents derived from mitochondria-targeting luminescent iridium(III) poly(ethylene glycol) complexes modified with a nitrobenzyl linkage. / Tso, Karson Ka-Shun; Leung, Kam-Keung; Liu, Hua-Wei et al.
In: Chemical Communications, Vol. 52, No. 24, 25.03.2016, p. 4557-4560.

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review