In vivo photodynamic therapy using upconversion nanoparticles as remote-controlled nanotransducers
Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review
Author(s)
Detail(s)
Original language | English |
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Pages (from-to) | 1580-1585 |
Journal / Publication | Nature Medicine |
Volume | 18 |
Issue number | 10 |
Publication status | Published - Oct 2012 |
Externally published | Yes |
Link(s)
Abstract
Conventional photodynamic therapy (PDT) is limited by the penetration depth of visible light needed for its activation. Here we used mesoporous-silica- coated upconversion fluorescent nanoparticles (UCNs) as a nanotransducer to convert deeply penetrating near-infrared light to visible wavelengths and a carrier of photosensitizers. We also used the multicolor-emission capability of the UCNs at a single excitation wavelength for simultaneous activation of two photosensitizers for enhanced PDT. We showed a greater PDT efficacy with the dual-photosensitizer approach compared to approaches using a single photosensitizer, as determined by enhanced generation of singlet oxygen and reduced cell viability. In vivo studies also showed tumor growth inhibition in PDT-treated mice by direct injection of UCNs into melanoma tumors or intravenous injection of UCNs conjugated with a tumor-targeting agent into tumor-bearing mice. As the first demonstration, to the best of our knowledge, of the photosensitizer-loaded UCN as an in vivo-targeted PDT agent, this finding may serve as a platform for future noninvasive deep-cancer therapy. © 2012 Nature America, Inc. All rights reserved.
Research Area(s)
Bibliographic Note
Publication details (e.g. title, author(s), publication statuses and dates) are captured on an “AS IS” and “AS AVAILABLE” basis at the time of record harvesting from the data source. Suggestions for further amendments or supplementary information can be sent to [email protected].
Citation Format(s)
In vivo photodynamic therapy using upconversion nanoparticles as remote-controlled nanotransducers. / Idris, Niagara Muhammad; Gnanasammandhan, Muthu Kumara; Zhang, Jing et al.
In: Nature Medicine, Vol. 18, No. 10, 10.2012, p. 1580-1585.
In: Nature Medicine, Vol. 18, No. 10, 10.2012, p. 1580-1585.
Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review