A Flexi-PEGDA Upconversion Implant for Wireless Brain Photodynamic Therapy

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review

64 Scopus Citations
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Author(s)

  • Daniel Boon Loong Teh
  • Akshaya Bansal
  • Chou Chai
  • Tan Boon Toh
  • Robert Alan Jappy Tucker
  • Gil Gerald Lasam Gammad
  • Yanzhuang Yeo
  • Zhendong Lei
  • Xiang Zheng
  • Fengyuan Yang
  • John S. Ho
  • Nagarjun Bolem
  • Bing Cheng Wu
  • Muthu Kumar Gnanasammandhan
  • Lissa Hooi
  • Gavin Stewart Dawe
  • Camilo Libedinsky
  • Wei-Yi Ong
  • Barry Halliwell
  • Edward Kai-Hua Chow
  • Kah-Leong Lim
  • Brian K. Kennedy

Detail(s)

Original languageEnglish
Article number2001459
Journal / PublicationAdvanced Materials
Volume32
Issue number29
Online published2 Jun 2020
Publication statusPublished - 23 Jul 2020
Externally publishedYes

Abstract

Near-infrared (NIR) activatable upconversion nanoparticles (UCNPs) enable wireless-based phototherapies by converting deep-tissue-penetrating NIR to visible light. UCNPs are therefore ideal as wireless transducers for photodynamic therapy (PDT) of deep-sited tumors. However, the retention of unsequestered UCNPs in tissue with minimal options for removal limits their clinical translation. To address this shortcoming, biocompatible UCNPs implants are developed to deliver upconversion photonic properties in a flexible, optical guide design. To enhance its translatability, the UCNPs implant is constructed with an FDA-approved poly(ethylene glycol) diacrylate (PEGDA) core clad with fluorinated ethylene propylene (FEP). The emission spectrum of the UCNPs implant can be tuned to overlap with the absorption spectra of the clinically relevant photosensitizer, 5-aminolevulinic acid (5-ALA). The UCNPs implant can wirelessly transmit upconverted visible light till 8 cm in length and in a bendable manner even when implanted underneath the skin or scalp. With this system, it is demonstrated that NIR-based chronic PDT is achievable in an untethered and noninvasive manner in a mouse xenograft glioblastoma multiforme (GBM) model. It is postulated that such encapsulated UCNPs implants represent a translational shift for wireless deep-tissue phototherapy by enabling sequestration of UCNPs without compromising wireless deep-tissue light delivery. © 2020 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Research Area(s)

  • hydrogels, optical fibers, photodynamic therapy, upconversion, wireless operation

Citation Format(s)

A Flexi-PEGDA Upconversion Implant for Wireless Brain Photodynamic Therapy. / Teh, Daniel Boon Loong; Bansal, Akshaya; Chai, Chou et al.
In: Advanced Materials, Vol. 32, No. 29, 2001459, 23.07.2020.

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review