Fabrication of micropillar substrates using replicas of alpha-particle irradiated and chemically etched PADC films

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  • C. K M Ng
  • E. Y W Chong
  • K. M C Cheung
  • K. W K Yeung


Original languageEnglish
Pages (from-to)1432-1435
Journal / PublicationApplied Radiation and Isotopes
Issue number7
Publication statusPublished - Jul 2012


We proposed a simple method to fabricate micropillar substrates. Polyallyldiglycol carbonate (PADC) films were irradiated by alpha particles and then chemically etched to form a cast with micron-scale spherical pores. A polydimethylsiloxane (PDMS) replica of this PADC film gave a micropillar substrate with micron-scale spherical pillars. HeLa cells cultured on such a micropillar substrate had significantly larger percentage of cells entering S-phase, attached cell numbers and cell spreading areas. © 2011 Elsevier Ltd.

Research Area(s)

  • Alpha particle, Cell proliferation, HeLa cells, Micropillar substrate, PADC, PDMS

Citation Format(s)