Three-Dimensional Printing of Self-Assembled Dipeptides

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review

18 Scopus Citations
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  • Jihyuk Yang
  • Mojun Chen
  • Heekwon Lee
  • Zhaoyi Xu
  • Zhiwen Zhou
  • Ji Tae Kim


Original languageEnglish
Pages (from-to)20573-20580
Journal / PublicationACS Applied Materials and Interfaces
Issue number17
Online published26 Apr 2021
Publication statusPublished - 5 May 2021
Externally publishedYes


Peptide-based materials are emerging as smart building blocks for nanobiodevices due to the programmability of their properties via the molecular constituents or arrangements. Many clever molecular self-assembly approaches have been devised to produce peptide crystalline structures. However, their freeform shaping remains a challenge due to the intrinsic self-assembly nature. Here, we report the fabrication of freeform, crystalline diphenylalanine (FF) peptide structures by combining meniscus-guided 3D printing with molecular self-assembly. Self-assembly in 3D-printed FF arises from mild thermal activation under precise temperature control of the build platform. After thorough characterizations, we demonstrate layer-by-layer, crystalline 3D printing with a high spatial resolution of 2 μm laterally and 200 nm vertically. The 3D-printed FF exhibits piezoelectricity originating from its crystalline character, showing the potential to become a key constituent for bioelectronic devices. We expect this technique to open up the possibility to create functional devices based on self-assembled organic materials without design restrictions.

Research Area(s)

  • 3D printing, dipeptides, diphenylalanine, piezoelectricity, self-assembly

Citation Format(s)

Three-Dimensional Printing of Self-Assembled Dipeptides. / Yang, Jihyuk; Chen, Mojun; Lee, Heekwon et al.
In: ACS Applied Materials and Interfaces, Vol. 13, No. 17, 05.05.2021, p. 20573-20580.

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review