Palladium-Catalyzed para-Selective Alkylation of Electron-Deficient Arenes
Research output: Journal Publications and Reviews (RGC: 21, 22, 62) › 21_Publication in refereed journal › peer-review
Author(s)
Related Research Unit(s)
Detail(s)
| Original language | English |
|---|---|
| Pages (from-to) | 6294-6298 |
| Journal / Publication | Angewandte Chemie - International Edition |
| Volume | 57 |
| Issue number | 21 |
| Online published | 12 Apr 2018 |
| Publication status | Published - 22 May 2018 |
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Abstract
Intermolecular alkylations of electron-deficient arenes proceed with good para selectivity. Palladium catalysts were used to generate nucleophilic alkyl radicals from alkyl halides, which then directly add onto the arenes. The arene scope and the site of alkylation are opposite to those of classical Friedel–Crafts alkylations, which prefer electron-rich systems.
Research Area(s)
- alkyl radicals, alkylation, arenes, palladium catalysis, synthetic methods
Citation Format(s)
Palladium-Catalyzed para-Selective Alkylation of Electron-Deficient Arenes. / Jiao, Zhiwei; Lim, Li Hui; Hirao, Hajime et al.
In: Angewandte Chemie - International Edition, Vol. 57, No. 21, 22.05.2018, p. 6294-6298.Research output: Journal Publications and Reviews (RGC: 21, 22, 62) › 21_Publication in refereed journal › peer-review
