Polymer-Brush-Grafted Mesoporous Silica Nanoparticles for Triggered Drug Delivery

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

28 Scopus Citations
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Author(s)

  • Ho Pan Bei
  • Yun Piao
  • Yufeng Wang
  • Mo Yang
  • Xin Zhao

Detail(s)

Original languageEnglish
Pages (from-to)1956-1964
Journal / PublicationChemPhysChem
Volume19
Issue number16
Online published24 Mar 2018
Publication statusPublished - 17 Aug 2018
Externally publishedYes

Abstract

Mesoporous silica nanoparticles (MSNs) have been demonstrated to be one of the most promising drug‐delivery systems (DDSs) to transport a variety of drugs/biomolecules. Functionalization of MSN surfaces with responsive polymer brushes leads to intelligent and controllable drug‐delivery properties, that is, the encapsulated drugs/biomolecules will only be released upon certain stimuli including pH, temperature, light, enzyme, ultrasound, or redox, thus maximizing their therapeutic efficiency and minimizing side effects. These polymer brushes can also increase the stability and extend the release period of the loaded cargoes. This Minireview presents an overview of recent research progress on stimuli‐responsive controlled DDSs based on polymer‐brush‐grafted MSNs. Utilizing the switching abilities of the grafted responsive polymer brushes, the smart DDSs show great potential for biomedical applications, especially for cancer therapy.

Research Area(s)

  • MSNs, polymer brushes, smart drug delivery

Citation Format(s)

Polymer-Brush-Grafted Mesoporous Silica Nanoparticles for Triggered Drug Delivery. / Zhang, Li; Bei, Ho Pan; Piao, Yun; Wang, Yufeng; Yang, Mo; Zhao, Xin.

In: ChemPhysChem, Vol. 19, No. 16, 17.08.2018, p. 1956-1964.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review