NIR-Responsive Photodynamic Nanosystem Combined with Antitumor Immune Optogenetics Bacteria for Precise Synergetic Therapy

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review

14 Scopus Citations
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Author(s)

  • Changsong Wu
  • Meihui Cui
  • Li Cai
  • Chen Chen
  • Xiaohui Zhu
  • Yihan Wu
  • Jinliang Liu
  • Hanjie Wang

Detail(s)

Original languageEnglish
Pages (from-to)13094-13106
Journal / PublicationACS Applied Materials and Interfaces
Volume14
Issue number11
Online published9 Mar 2022
Publication statusPublished - 23 Mar 2022
Externally publishedYes

Abstract

Photodynamic therapy (PDT) and immunotherapy are considered promising methods for the treatment of tumors. However, these treatment systems are still suffering from shortcomings such as hypoxia, easy metastasis, and delayed immune response during PDT. Therefore, it is still challenging to establish a programmed and rapid response immune combination therapy platform. Here, we construct a two-step synergetic therapy platform for the treatment of primary tumors and distant tumors using upconversion nanoparticles (UCNPs) and engineered bacteria as therapeutic media. In the first step, erbium ion (Er3+)-doped UCNPs act as a photoswitcher to activate the photosensitizer ZnPc to produce 1O2 for primary tumor therapy. In the second step, thulium ion (Tm3+)-doped UCNPs can emit blue-violet light under the excitation of near-infrared (NIR) light to activate the engineered bacteria to produce interferon (INF-γ) and release them in the intestine, which can not only treat tumors directly but also act with PDT to regulate immune pathways to activate the immune system, resulting in a joint immunotherapy effect to inhibit the growth of distant tumors. As a new type of programmatic combination therapy, we have proved that this platform can jointly activate the body's immune system during PDT and immunization treatment and can effectively inhibit tumor metastasis. © 2022 American Chemical Society.

Research Area(s)

  • engineering bacteria, enhanced PDT, immune combination therapy, optogenetics, UCNPs

Citation Format(s)

NIR-Responsive Photodynamic Nanosystem Combined with Antitumor Immune Optogenetics Bacteria for Precise Synergetic Therapy. / Wu, Changsong; Cui, Meihui; Cai, Li et al.
In: ACS Applied Materials and Interfaces, Vol. 14, No. 11, 23.03.2022, p. 13094-13106.

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review