A Graphene Oxide-based Covalent Resorufin-Conjugated Fluorescence “OFF-ON” Probe for Detection of Hydrazine
Research output: Journal Publications and Reviews (RGC: 21, 22, 62) › 21_Publication in refereed journal › peer-review
Author(s)
Related Research Unit(s)
Detail(s)
| Original language | English |
|---|---|
| Article number | e202200060 |
| Journal / Publication | Chemistry - An Asian Journal |
| Volume | 17 |
| Issue number | 12 |
| Online published | 12 Apr 2022 |
| Publication status | Published - 15 Jun 2022 |
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Abstract
The unique properties of graphene oxide (GO), such as good water solubility, non-toxicity, biocompatibility and cell permeability, make GO well suited for a number of biological applications. In this study, we explore the application of GO as an efficient fluorescent quencher for a highly fluorescent organic dye, resorufin (RF). The quenching effect of GO on resorufin is studied by noncovalent and covalent bonding of resorufin, respectively. The fluorescence is completely quenched when resorufin is covalently linked to GO; while resorufin's fluorescence could be still observed through noncovalent bonding to GO sheet. Interestingly, addition of hydrazine into RF-GO complex causes the fluorescence recovered, providing a potential ‘‘OFF-ON’’ fluorescence responsive probe for detecting hydrazine in vitro and in living cells.
Research Area(s)
- covalent bonding, fluorescence quench, graphene oxide, hydrazine, resorufin
Citation Format(s)
A Graphene Oxide-based Covalent Resorufin-Conjugated Fluorescence “OFF-ON” Probe for Detection of Hydrazine. / Guo, Qiang; Zhang, Jie; Sun, Hongyan et al.
In: Chemistry - An Asian Journal, Vol. 17, No. 12, e202200060, 15.06.2022.Research output: Journal Publications and Reviews (RGC: 21, 22, 62) › 21_Publication in refereed journal › peer-review
