Promoter hypermethylation mediates downregulation of thiamine receptor SLC19A3 in gastric cancer

Xin Liu; Emily K.Y. Lam; Xian Wang; Jianbin Zhang; Yuen Yee Cheng; Yun W. Lam; Enders K.O. Ng; Jun Yu; Francis K.L. Chan; Hongchuan Jin; Joseph J.Y. Sung

doi:10.1159/000243767

Promoter hypermethylation mediates downregulation of thiamine receptor SLC19A3 in gastric cancer

Xin Liu, Emily K.Y. Lam, Xian Wang, Jianbin Zhang, Yuen Yee Cheng, Yun W. Lam, Enders K.O. Ng, Jun Yu, Francis K.L. Chan, Hongchuan Jin, Joseph J.Y. Sung

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

29 Citations (Scopus)

Abstract

As an important way to inactivate tumor suppressor genes (TSGs) during cancer development, promoter hypermethylation can be used to define novel TSGs and identify biomarkers for cancer diagnosis. SLC19A3 (solute carrier family 19, member 3) was found to be such a biomarker. SLC19A3 expression was downregulated in gastric cancer cell lines (71%, 5/7) and restored after pharmacological demethylation. Notably, hypermethylation of SLC19A3 promoter was detected in gastric cancer cell lines (57%, 4/7), primary gastric carcinoma tissues (51%, 52/101) and precancerous lesion (intestinal metaplasia) tissues (32%, 8/25). Exogenous SLC19A3 expression caused growth inhibition of gastric cancer cells. In summary, SLC19A3 was epigenetically downregulated in gastric cancer. Methylation of SLC19A3 promoter could be a novel biomarker for early gastric cancer development. © 2009 S. Karger AG, Basel.

Original language	English
Pages (from-to)	242-248
Journal	Tumor Biology
Volume	30
Issue number	5-6
DOIs	https://doi.org/10.1159/000243767
Publication status	Published - Dec 2009

Research Keywords

Gastric cancer
Methylation
SLC19A3

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title = "Promoter hypermethylation mediates downregulation of thiamine receptor SLC19A3 in gastric cancer",

abstract = "As an important way to inactivate tumor suppressor genes (TSGs) during cancer development, promoter hypermethylation can be used to define novel TSGs and identify biomarkers for cancer diagnosis. SLC19A3 (solute carrier family 19, member 3) was found to be such a biomarker. SLC19A3 expression was downregulated in gastric cancer cell lines (71%, 5/7) and restored after pharmacological demethylation. Notably, hypermethylation of SLC19A3 promoter was detected in gastric cancer cell lines (57%, 4/7), primary gastric carcinoma tissues (51%, 52/101) and precancerous lesion (intestinal metaplasia) tissues (32%, 8/25). Exogenous SLC19A3 expression caused growth inhibition of gastric cancer cells. In summary, SLC19A3 was epigenetically downregulated in gastric cancer. Methylation of SLC19A3 promoter could be a novel biomarker for early gastric cancer development. {\textcopyright} 2009 S. Karger AG, Basel.",

keywords = "Gastric cancer, Methylation, SLC19A3",

author = "Xin Liu and Lam, {Emily K.Y.} and Xian Wang and Jianbin Zhang and Cheng, {Yuen Yee} and Lam, {Yun W.} and Ng, {Enders K.O.} and Jun Yu and Chan, {Francis K.L.} and Hongchuan Jin and Sung, {Joseph J.Y.}",

year = "2009",

month = dec,

doi = "10.1159/000243767",

language = "English",

volume = "30",

pages = "242--248",

journal = "Tumor Biology",

issn = "1010-4283",

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TY - JOUR

T1 - Promoter hypermethylation mediates downregulation of thiamine receptor SLC19A3 in gastric cancer

AU - Liu, Xin

AU - Lam, Emily K.Y.

AU - Wang, Xian

AU - Zhang, Jianbin

AU - Cheng, Yuen Yee

AU - Lam, Yun W.

AU - Ng, Enders K.O.

AU - Yu, Jun

AU - Chan, Francis K.L.

AU - Jin, Hongchuan

AU - Sung, Joseph J.Y.

PY - 2009/12

Y1 - 2009/12

N2 - As an important way to inactivate tumor suppressor genes (TSGs) during cancer development, promoter hypermethylation can be used to define novel TSGs and identify biomarkers for cancer diagnosis. SLC19A3 (solute carrier family 19, member 3) was found to be such a biomarker. SLC19A3 expression was downregulated in gastric cancer cell lines (71%, 5/7) and restored after pharmacological demethylation. Notably, hypermethylation of SLC19A3 promoter was detected in gastric cancer cell lines (57%, 4/7), primary gastric carcinoma tissues (51%, 52/101) and precancerous lesion (intestinal metaplasia) tissues (32%, 8/25). Exogenous SLC19A3 expression caused growth inhibition of gastric cancer cells. In summary, SLC19A3 was epigenetically downregulated in gastric cancer. Methylation of SLC19A3 promoter could be a novel biomarker for early gastric cancer development. © 2009 S. Karger AG, Basel.

AB - As an important way to inactivate tumor suppressor genes (TSGs) during cancer development, promoter hypermethylation can be used to define novel TSGs and identify biomarkers for cancer diagnosis. SLC19A3 (solute carrier family 19, member 3) was found to be such a biomarker. SLC19A3 expression was downregulated in gastric cancer cell lines (71%, 5/7) and restored after pharmacological demethylation. Notably, hypermethylation of SLC19A3 promoter was detected in gastric cancer cell lines (57%, 4/7), primary gastric carcinoma tissues (51%, 52/101) and precancerous lesion (intestinal metaplasia) tissues (32%, 8/25). Exogenous SLC19A3 expression caused growth inhibition of gastric cancer cells. In summary, SLC19A3 was epigenetically downregulated in gastric cancer. Methylation of SLC19A3 promoter could be a novel biomarker for early gastric cancer development. © 2009 S. Karger AG, Basel.

KW - Gastric cancer

KW - Methylation

KW - SLC19A3

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U2 - 10.1159/000243767

DO - 10.1159/000243767

M3 - RGC 21 - Publication in refereed journal

C2 - 19816091

SN - 1010-4283

VL - 30

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EP - 248

JO - Tumor Biology

JF - Tumor Biology

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ER -

Promoter hypermethylation mediates downregulation of thiamine receptor SLC19A3 in gastric cancer

Abstract

Research Keywords

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