Promising advancement in fermentative succinic acid production by yeast hosts

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

8 Scopus Citations
View graph of relations

Author(s)

  • Zhiyong Cui
  • Zhenyu Sang
  • Raffel Dharma Patria
  • Qingsheng Qi
  • Patrick Fickers
  • Jianbin Yan

Related Research Unit(s)

Detail(s)

Original languageEnglish
Article number123414
Journal / PublicationJournal of Hazardous Materials
Volume401
Online published8 Jul 2020
Publication statusPublished - 5 Jan 2021

Abstract

As a platform chemical with various applications, succinic acid (SA) is currently produced by petrochemical processing from oil-derived substrates such as maleic acid. In order to replace the environmental unsustainable hydrocarbon economy with a renewable environmentally sound carbohydrate economy, bio-based SA production process has been developed during the past two decades. In this review, recent advances in the valorization of solid organic wastes including mixed food waste, agricultural waste and textile waste for efficient, green and sustainable SA production have been reviewed. Firstly, the application, market and key global players of bio-SA are summarized. Then achievements in SA production by several promising yeasts including Saccharomyces cerevisiae and Yarrowia lipolytica are detailed, followed by calculation and comparison of SA production costs between oil-based substrates and raw materials. Lastly, challenges in engineered microorganisms and fermentation processes are presented together with perspectives on the development of robust yeast SA producers via genome-scale metabolic optimization and application of low-cost raw materials as fermentation substrates. This review provides valuable insights for identifying useful directions for future bio-SA production improvement.

Research Area(s)

  • Engineering strategies, Key producers, Renewable resources, Saccharomyces cerevisiae, Yarrowia lipolytica

Citation Format(s)

Promising advancement in fermentative succinic acid production by yeast hosts. / Li, Chong; Ong, Khai Lun; Cui, Zhiyong; Sang, Zhenyu; Li, Xiaotong; Patria, Raffel Dharma; Qi, Qingsheng; Fickers, Patrick; Yan, Jianbin; Lin, Carol Sze Ki.

In: Journal of Hazardous Materials, Vol. 401, 123414, 05.01.2021.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review