Prolonged monitoring and risk management of hyperuricemia using interference-resistant wearable bioelectronics

Yue Hu; Yawen Yang; Hongwei Chu; Rui Shi; Jiyu Li; Guoqiang Xu; Xingcan Huang; Binbin Zhang; Chun Ki Yiu; Guangyao Zhao; Pengcheng Wu; Jian Li; Yuan Guo; Qiang Zhang; Mengge Wu; Jingkun Zhou; Yingchun Li; Zhengchun Peng; Xinge Yu

doi:10.1016/j.device.2025.100753

Prolonged monitoring and risk management of hyperuricemia using interference-resistant wearable bioelectronics

Yue Hu (Co-first Author)
, Yawen Yang (Co-first Author)
, Hongwei Chu (Co-first Author)
, Rui Shi (Co-first Author)
, Jiyu Li
, Guoqiang Xu
, Xingcan Huang
, Binbin Zhang
, Chun Ki Yiu
, Guangyao Zhao
, Pengcheng Wu
, Jian Li
, Yuan Guo
, Qiang Zhang
, Mengge Wu
, Jingkun Zhou
, Yingchun Li
, Zhengchun Peng
, Xinge Yu^*

^*Corresponding author for this work

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

12 Citations (Scopus)

Abstract

We report a prolonged wearable biosensing system for monitoring hyperuricemia (HUA), a prevalent metabolic disorder resulting from abnormal purine metabolism, from sweat, with reliable and stable behaviors for up to 15 days. This reusable wearable system integrates an interference-resistant HUA biosensor, a microfluidic module for autonomous sweat collection, a conformable device-skin adhesive interface with adjustable adhesion strength, and a flexible circuit board for data acquisition and transmission. A customized mobile application provides real-time HUA levels and associated risks, facilitating timely self-regulation and long-term dietary and health management. The HUA sensing signal of sweat was compared and calibrated with clinical standard by serum tests for 80 volunteers, where the results exhibited great correlation and thus can be used as assessing criteria. On-body tracking validation further highlighted the great potential of our wearable bioelectronics for the development of individualized diagnostic protocols. © 2025 Elsevier Inc.

Original language	English
Article number	100753
Journal	Device
Volume	3
Issue number	7
Online published	27 Mar 2025
DOIs	https://doi.org/10.1016/j.device.2025.100753
Publication status	Published - 18 Jul 2025

Funding

This work was supported by the National Natural Science Foundation of China (grant no. 62122002); the City University of Hong Kong (grant nos. 9667221, 9678274, and 9610444), as part of the InnoHK Project 2.2\u2013AI-based 3D ultrasound imaging algorithm at Hong Kong Center for Cerebro-cardiovascular Health Engineering (COCHE); the Research Grants Council of the Hong Kong Special Administrative Region (grant nos. RFS2324-1S03, 11213721, 11215722, and 11211523); and the Shenzhen Science and Technology Innovation Commission (grant no. SGDX20220530111401011).

Research Keywords

chronic disease surveillance
comfortable interface
daily self-monitoring
DTI-3: Develop
hyperuricemia monitoring
interference-resistant bioelectronics
long-term biosignal tracking
reusable sweat sensors
uric acid determination
wearable device

RGC Funding Information

RGC-funded

Access Output

10.1016/j.device.2025.100753

Other Access Options

Check CityUHK Library

Permanent Link

Right click to copy link

Cite this

Hu, Y., Yang, Y., Chu, H., Shi, R., Li, J., Xu, G., Huang, X., Zhang, B., Yiu, C. K., Zhao, G., Wu, P., Li, J., Guo, Y., Zhang, Q., Wu, M., Zhou, J., Li, Y., Peng, Z., & Yu, X. (2025). Prolonged monitoring and risk management of hyperuricemia using interference-resistant wearable bioelectronics. Device, 3(7), Article 100753. https://doi.org/10.1016/j.device.2025.100753

@article{014a495ad64840acacae2ce3848d4fd7,

title = "Prolonged monitoring and risk management of hyperuricemia using interference-resistant wearable bioelectronics",

abstract = "We report a prolonged wearable biosensing system for monitoring hyperuricemia (HUA), a prevalent metabolic disorder resulting from abnormal purine metabolism, from sweat, with reliable and stable behaviors for up to 15 days. This reusable wearable system integrates an interference-resistant HUA biosensor, a microfluidic module for autonomous sweat collection, a conformable device-skin adhesive interface with adjustable adhesion strength, and a flexible circuit board for data acquisition and transmission. A customized mobile application provides real-time HUA levels and associated risks, facilitating timely self-regulation and long-term dietary and health management. The HUA sensing signal of sweat was compared and calibrated with clinical standard by serum tests for 80 volunteers, where the results exhibited great correlation and thus can be used as assessing criteria. On-body tracking validation further highlighted the great potential of our wearable bioelectronics for the development of individualized diagnostic protocols. {\textcopyright} 2025 Elsevier Inc.",

keywords = "chronic disease surveillance, comfortable interface, daily self-monitoring, DTI-3: Develop, hyperuricemia monitoring, interference-resistant bioelectronics, long-term biosignal tracking, reusable sweat sensors, uric acid determination, wearable device",

author = "Yue Hu and Yawen Yang and Hongwei Chu and Rui Shi and Jiyu Li and Guoqiang Xu and Xingcan Huang and Binbin Zhang and Yiu, \{Chun Ki\} and Guangyao Zhao and Pengcheng Wu and Jian Li and Yuan Guo and Qiang Zhang and Mengge Wu and Jingkun Zhou and Yingchun Li and Zhengchun Peng and Xinge Yu",

year = "2025",

month = jul,

day = "18",

doi = "10.1016/j.device.2025.100753",

language = "English",

volume = "3",

number = "7",

}

TY - JOUR

T1 - Prolonged monitoring and risk management of hyperuricemia using interference-resistant wearable bioelectronics

AU - Hu, Yue

AU - Yang, Yawen

AU - Chu, Hongwei

AU - Shi, Rui

AU - Li, Jiyu

AU - Xu, Guoqiang

AU - Huang, Xingcan

AU - Zhang, Binbin

AU - Yiu, Chun Ki

AU - Zhao, Guangyao

AU - Wu, Pengcheng

AU - Li, Jian

AU - Guo, Yuan

AU - Zhang, Qiang

AU - Wu, Mengge

AU - Zhou, Jingkun

AU - Li, Yingchun

AU - Peng, Zhengchun

AU - Yu, Xinge

PY - 2025/7/18

Y1 - 2025/7/18

N2 - We report a prolonged wearable biosensing system for monitoring hyperuricemia (HUA), a prevalent metabolic disorder resulting from abnormal purine metabolism, from sweat, with reliable and stable behaviors for up to 15 days. This reusable wearable system integrates an interference-resistant HUA biosensor, a microfluidic module for autonomous sweat collection, a conformable device-skin adhesive interface with adjustable adhesion strength, and a flexible circuit board for data acquisition and transmission. A customized mobile application provides real-time HUA levels and associated risks, facilitating timely self-regulation and long-term dietary and health management. The HUA sensing signal of sweat was compared and calibrated with clinical standard by serum tests for 80 volunteers, where the results exhibited great correlation and thus can be used as assessing criteria. On-body tracking validation further highlighted the great potential of our wearable bioelectronics for the development of individualized diagnostic protocols. © 2025 Elsevier Inc.

AB - We report a prolonged wearable biosensing system for monitoring hyperuricemia (HUA), a prevalent metabolic disorder resulting from abnormal purine metabolism, from sweat, with reliable and stable behaviors for up to 15 days. This reusable wearable system integrates an interference-resistant HUA biosensor, a microfluidic module for autonomous sweat collection, a conformable device-skin adhesive interface with adjustable adhesion strength, and a flexible circuit board for data acquisition and transmission. A customized mobile application provides real-time HUA levels and associated risks, facilitating timely self-regulation and long-term dietary and health management. The HUA sensing signal of sweat was compared and calibrated with clinical standard by serum tests for 80 volunteers, where the results exhibited great correlation and thus can be used as assessing criteria. On-body tracking validation further highlighted the great potential of our wearable bioelectronics for the development of individualized diagnostic protocols. © 2025 Elsevier Inc.

KW - chronic disease surveillance

KW - comfortable interface

KW - daily self-monitoring

KW - DTI-3: Develop

KW - hyperuricemia monitoring

KW - interference-resistant bioelectronics

KW - long-term biosignal tracking

KW - reusable sweat sensors

KW - uric acid determination

KW - wearable device

UR - https://www.scopus.com/pages/publications/105001350049

UR - https://www.scopus.com/record/pubmetrics.uri?eid=2-s2.0-105001350049&origin=recordpage

U2 - 10.1016/j.device.2025.100753

DO - 10.1016/j.device.2025.100753

M3 - RGC 21 - Publication in refereed journal

SN - 2666-9986

VL - 3

JO - Device

JF - Device

IS - 7

M1 - 100753

ER -

Prolonged monitoring and risk management of hyperuricemia using interference-resistant wearable bioelectronics

Abstract

Funding

Research Keywords

RGC Funding Information

Access Output

Other Access Options

Permanent Link

Other Files and Links

Fingerprint

RFS: Skin-Integrated and Multi-functional Closed Loop Human Machine Interface: Sensing, Actuation, and System Integration

GRF: Thin, Soft, Skin-integrated Olfactory Interface

GRF: Intelligent Skin-integrated Haptic Interface with Multiple Feedback Modes

Cite this

Prolonged monitoring and risk management of hyperuricemia using interference-resistant wearable bioelectronics

Abstract

Funding

Research Keywords

RGC Funding Information

Access Output

Other Access Options

Permanent Link

Other Files and Links

Fingerprint

Projects

RFS: Skin-Integrated and Multi-functional Closed Loop Human Machine Interface: Sensing, Actuation, and System Integration

GRF: Thin, Soft, Skin-integrated Olfactory Interface

GRF: Intelligent Skin-integrated Haptic Interface with Multiple Feedback Modes

Cite this