Progress of gelatin-based microspheres (GMSs) as delivery vehicles of drug and cell

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

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Author(s)

  • Zuoxiang Dong
  • Xinyue Meng
  • Wei Yang
  • Jinfeng Zhang
  • Peng Sun
  • Huawei Zhang
  • Xing Fang
  • Changjiang Fan

Detail(s)

Original languageEnglish
Article number111949
Journal / PublicationMaterials Science and Engineering C
Volume122
Online published6 Feb 2021
Publication statusPublished - Mar 2021

Abstract

Gelatin has various attractive features as biomedical materials, for instance, biocompatibility, low immunogenicity, biodegradability, and ease of manipulation. In recent years, various gelatin-based microspheres (GMSs) have been fabricated with innovative technologies to serve as sustained delivery vehicles of drugs and genetic materials as well as beneficial bacteria. Moreover, GMSs have exhibited promising potentials to act as both cell carriers and 3D scaffold components in tissue engineering and regenerative medicine, which not only exhibit excellent injectability but also could be integrated into a macroscale construct with the laden cells. Herein, we aim to thoroughly summarize the recent progress in the preparations and biomedical applications of GMSs and then to point out the research direction in future. First, various methods for the fabrication of GMSs will be described. Second, the recent use of GMSs in tumor embolization and in the delivery of cells, drugs, and genetic material as well as bacteria will be presented. Finally, several key factors that may enhance the improvement of GMSs were suggested as delivery vehicles.

Research Area(s)

  • Drug delivery, Embolization, Gelatin, Microspheres, Tissue engineering

Citation Format(s)

Progress of gelatin-based microspheres (GMSs) as delivery vehicles of drug and cell. / Dong, Zuoxiang; Meng, Xinyue; Yang, Wei et al.
In: Materials Science and Engineering C, Vol. 122, 111949, 03.2021.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review