Programmed surface on poly(aryl-ether-ether-ketone) initiating immune mediation and fulfilling bone regeneration sequentially

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review

57 Scopus Citations
View graph of relations

Author(s)

  • Lingxia Xie
  • Qing Liao
  • Xiaoxue Ren
  • Liping Tong
  • Wei Zhang
  • Min Guan
  • Haobo Pan
  • Huaiyu Wang

Detail(s)

Original languageEnglish
Article number100148
Journal / PublicationInnovation(United States)
Volume2
Issue number3
Online published5 Aug 2021
Publication statusPublished - 28 Aug 2021

Link(s)

Abstract

The immune responses are involved in every stage after implantation but the reported immune-regulated materials only work at the beginning without fully considering the different phases of bone healing. Here, poly(aryl-ether-ether-ketone) (PEEK) is coated with a programmed surface, which rapidly releases interleukin-10 (IL-10) in the first week and slowly delivers dexamethasone (DEX) up to 4 weeks. Owing to the synergistic effects of IL-10 and DEX, an aptly weak inflammation is triggered within the first week, followed by significant M2 polarization of macrophages and upregulation of the autophagy-related factors. The suitable immunomodulatory activities pave the way for osteogenesis and the steady release of DEX facilitates bone regeneration thereafter. The sequential immune-mediated process is also validated by an 8-week implementation on a rat model. This is the first attempt to construct implants by taking advantage of both immune-mediated modulation and sequential regulation spanning all bone regeneration phases, which provides insights into the fabrication of advanced biomaterials for tissue engineering and immunological therapeutics.

Research Area(s)

  • bone regeneration, immune-mediated osteogenesis, poly(aryl-ether-ether-ketone), sequential release, surface modifications

Citation Format(s)

Programmed surface on poly(aryl-ether-ether-ketone) initiating immune mediation and fulfilling bone regeneration sequentially. / Xie, Lingxia; Wang, Guomin; Wu, Yuzheng et al.
In: Innovation(United States), Vol. 2, No. 3, 100148, 28.08.2021.

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review

Download Statistics

No data available